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Database: UniProt
Entry: B6GDM4_9ACTN
LinkDB: B6GDM4_9ACTN
Original site: B6GDM4_9ACTN 
ID   B6GDM4_9ACTN            Unreviewed;       625 AA.
AC   B6GDM4;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   25-OCT-2017, entry version 60.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=COLSTE_02207 {ECO:0000313|EMBL:EEA89663.1};
OS   Collinsella stercoris DSM 13279.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Coriobacteriaceae; Collinsella.
OX   NCBI_TaxID=445975 {ECO:0000313|EMBL:EEA89663.1, ECO:0000313|Proteomes:UP000003560};
RN   [1] {ECO:0000313|EMBL:EEA89663.1, ECO:0000313|Proteomes:UP000003560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13279 {ECO:0000313|EMBL:EEA89663.1,
RC   ECO:0000313|Proteomes:UP000003560};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M.,
RA   Liep D., Gordon J.;
RT   "Draft genome sequence of Collinsella stercoris (DSM 13279).";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEA89663.1, ECO:0000313|Proteomes:UP000003560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13279 {ECO:0000313|EMBL:EEA89663.1,
RC   ECO:0000313|Proteomes:UP000003560};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H.,
RA   Johnson M., Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R.,
RA   Wilson R.K.;
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEA89663.1}.
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DR   EMBL; ABXJ01000128; EEA89663.1; -; Genomic_DNA.
DR   ProteinModelPortal; B6GDM4; -.
DR   STRING; 445975.COLSTE_02207; -.
DR   EnsemblBacteria; EEA89663; EEA89663; COLSTE_02207.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000003560; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003560};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003560}.
FT   DOMAIN      531    600       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   625 AA;  68609 MW;  C17601F0FB0A0F7F CRC64;
     MCKMENEARI LLDDVIEFCR RDGREPRLIN MLEQCGASDF DDESLTVAVP SRFACTYLEK
     QREVIEGYLE EISFMPMRLE VVVEDRNAGC RGAGKRTAAA VEATPGAGEP TLASILAQAE
     QDDDAPEDMA TFPGVFDHVP AYAEAGRVGG APEPSPVPRA GRPNNMQADA MNPAPIPSPA
     PASPHKQAGT EEARSGINVV NTVSADTFRR MMQEMRGAQA SGTAGASARV ADGHYGPSAA
     SGGGVAPAAR MDDAPVADIN AKYTFESFVA GDENRHAFNS AMRFAAFAEE PGQCPSLFIY
     GNSGLGKTHL LFAVRNYLAK EKPYIRVKYA NSQAYLDDYM NELGTQRGPG SLIMREYRDA
     DILIIDDVQN IVGKQASVEF FFQLVDSFIR EGKKIAFASD RAPKDLAMDE RLTSRFSRGM
     LCLVSEPGFE MKYVILKRYY ENIINGSESL DGLNVDTSLL SMLPEHEGHL TDEHLRHMAE
     ISGNNIRNLE SFCERCAGLA AEREAAGGEL SAEDIDETAK TYFNTARKVI HIDTVQRVVE
     EFYHVSHEEL IGPRRTASIA FARHVAVYLA NSLCEMTTPA IGAEFGGRDH STVLNSLKVV
     ENKMREDRRI CEDLQNLKNT IMLKS
//
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