ID B6H7R6_PENRW Unreviewed; 537 AA.
AC B6H7R6;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Pc16g08140 protein {ECO:0000313|EMBL:CAP93484.1};
GN ORFNames=Pc16g08140 {ECO:0000313|EMBL:CAP93484.1}, PCH_Pc16g08140
GN {ECO:0000313|EMBL:CAP93484.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP93484.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP93484.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
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DR EMBL; AM920431; CAP93484.1; -; Genomic_DNA.
DR RefSeq; XP_002561136.1; XM_002561090.1.
DR AlphaFoldDB; B6H7R6; -.
DR CAZy; GH43; Glycoside Hydrolase Family 43.
DR GeneID; 8311347; -.
DR KEGG; pcs:Pc16g08140; -.
DR VEuPathDB; FungiDB:PCH_Pc16g08140; -.
DR eggNOG; ENOG502QQH8; Eukaryota.
DR HOGENOM; CLU_016508_2_0_1; -.
DR OMA; GEVQWIQ; -.
DR OrthoDB; 1891044at2759; -.
DR BioCyc; PCHR:PC16G08140-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c16.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd18617; GH43_XynB-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF12; BETA-XYLOSIDASE-RELATED; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 323..533
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT ACT_SITE 13
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 186
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 126
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 537 AA; 60374 MW; 564E55207882D62E CRC64;
MYNNPIIPGF NPDPSIIRVG ADFFLVTSTF EYTPGAPIYH STDLIKWSLI GHALTRPSQL
QIQTPEPGGG IWATTIRYHD GVYYILAASF TRYRPQADDR VWPRGFYVST TDIWDESSWS
DPVWFDQLFW DDGGTVYLSS TYRKQPRTPG PPLKDFAIHV STVDLASGSA TSIPKMIRSS
PSGVSEGSHI FKRGKYYYLF TAEGGTESGH CEWVFRSEAS PFGSWEVGPS NPLWRNGLID
EIQNTGHADL VEDTEGRWWA VFLGVRPVKK ENGWEERVFG RETFLVPLEW TPDGWPIING
GEKVTSRNTS SLLYEYEPPV AWSDDFTSPK LQLGWYRKNT PLKKDYTLLP EKGLLRLHGS
PYTLSTPACP TLFLRKQTHR FCIWETRLSF SPNSANTEAG TVVYLNYFTW ASVGVRLASQ
SSEDGKRTIR FTPSNLGPGH EPIDIPLSGS TSDVILRVGC GDGYRFGFKE VEAEDREDGQ
DGEVQWIQEV GNKSLVEAPL PVGAPFTGMM LGLYSFGDRE AVLVPADFKY VEFRGRE
//
