ID B6HCF6_PENRW Unreviewed; 1644 AA.
AC B6HCF6;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE SubName: Full=Pc18g01560 protein {ECO:0000313|EMBL:CAP94380.1};
GN ORFNames=Pc18g01560 {ECO:0000313|EMBL:CAP94380.1}, PCH_Pc18g01560
GN {ECO:0000313|EMBL:CAP94380.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP94380.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP94380.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
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DR EMBL; AM920433; CAP94380.1; -; Genomic_DNA.
DR RefSeq; XP_002562000.1; XM_002561954.1.
DR STRING; 500485.B6HCF6; -.
DR GeneID; 8314219; -.
DR KEGG; pcs:Pc18g01560; -.
DR VEuPathDB; FungiDB:PCH_Pc18g01560; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_001471_0_0_1; -.
DR OMA; ICNYATM; -.
DR OrthoDB; 5476208at2759; -.
DR BioCyc; PCHR:PC18G01560-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c18.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 367..491
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1398..1641
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 66..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..711
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1644 AA; 182291 MW; 7047580B6602BD0E CRC64;
MEPFPPPTHP EFKDAFLGPQ VQINELSASN RMPSGPQNPI SNLRRANTVA QGGNVKRNLE
LKAARERTAT GINAKDSHEL LRQNKLQRSQ THRGPLEARP PGRKAGHFTV RSVGQNGKIF
LRPIANPPQK SPQPASFSPV DTAKPSLLQP QSHAHAREDP DPSRWSSSQL SELRPREQPK
DPEPVLAVSP ELSSQHRTRP ISFSTISEQQ SIAGAGKRGE LRIVIDRSED RPKSARENST
PALEVPIPRY QLGSPRFNAE GSAMMQSSVY TRTSMSDNFR NSTLLGGMAD PLPGLHSPYP
RDSFSRHRPS FAISMFSGTA AAMDMNRASP APRNSMVYEL KEPVEPSIYE TLVYDMDDGS
VVRYIPGTKD ISAATPARIV AQISSESFMD YELVSDFFLT FRSYLSTTHL LALLLARLKW
AINRLQDDGR IIRIRTFAAL RHWILNYFVD DFVTNYELRT NFCETINKLY SEVRSRHNGG
TSDRKILIDL KRCWNGKCSV YWSSPQLSRA YNDPEIPIVP GDAQIELPKA GELQQSVPTY
GMAPNADTTF RESPIQHDRN DSAATTQSIP FSAKSDQSLM ALSCSLPPKS PKRLSMCASK
GKAPRPVVLG LTKSKPPSNT HEPPRSPVSP MVSRHPYHSH SHKRSGSFSD SVRDDRVPMF
AVEPDTGPAP QEILDPVSLI RGEMYPPAES YMTMMAPESP PLPPPLKNPN PDRRSTPDVP
KSSPNSGVRT IIGSIKRALH TRNGGQSVSA RIANAHEAIS LPSRGKTSAM PTGLAFGSEF
YRERKMAAIP KYPGRIDVLC DEVLKQYRLA MNQEGTKDQT QPPAASDFHQ AAAGEPASNT
SNLLPTQTPK PDPKLRSGIT MGSESIIIVD DTGFEMPFMS GAAQKPGRIA NDETHETPEI
EVLDDTSTQS IPVEGEYLQP ICYKADEPES AAQSNVFYPL RPLTPQRSSS VERGSTPVKE
KKNSLSLRLR KYASFQSGIS RQRFSMSSET ALSTVDSNAM QDQNHKQSGP VLRRRRGGNL
RQMQTGNGTE PPSCRDSFAS WGDSVVDETV PSDGDESRPP STLIPPNPRY SLIRPHTSRQ
IRRSFESVIA KFAQIPDDDD GGIESTLLKL EGKWNGPPST DRDSNSHREQ PLGPHYGETA
RPGWDIISRR RQTDKSSYST VGGRLAPPRP YSDSVTESEE SYNSIPLLER GLADESMKSQ
PTSQPFQYDL HVAPLTLVSS HETSELASSN PSIQIVHETD SMRRIPRGAT IPASATDNAG
QVTPKHFSAL SSEMSVDLID PHEAMDARIS TDARSLGSST VEIPPHPLAQ PPSPPMTIQH
PGSFASYPSP LNTVLFQTQP LTPDTSPRHK EVGISASRPL DIQQISSDVL FNSENNCTDQ
NPVINLLPDH VPFILACESQ VLAHQLTLIE MAALSEIDWR DLVEMKWSNA SPLVTNWVQF
LTCEERKGID LVVGRFNLMV KWILSEIVLT RDINERARTI IKYIHTAAHA RRICNYATML
QIAIALSSSD CSRLHRTWQL ISLEDKRLFK DMECLIQPVR NFNDLRVEME TANLQEGCIP
FIGLYVHDLT YNAQKPAQVS NTDGGLLVNF ERYRTAARIV KSLLRLIDAS AKYKFEPVQG
IIERCLWIAC LPEDEIQSRS KALE
//