ID B6HNN0_PENRW Unreviewed; 800 AA.
AC B6HNN0;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Pc21g09450 protein {ECO:0000313|EMBL:CAP95842.1};
GN ORFNames=Pc21g09450 {ECO:0000313|EMBL:CAP95842.1}, PCH_Pc21g09450
GN {ECO:0000313|EMBL:CAP95842.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP95842.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP95842.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; AM920436; CAP95842.1; -; Genomic_DNA.
DR RefSeq; XP_002567984.1; XM_002567938.1.
DR AlphaFoldDB; B6HNN0; -.
DR STRING; 500485.B6HNN0; -.
DR GeneID; 8304110; -.
DR KEGG; pcs:Pc21g09450; -.
DR VEuPathDB; FungiDB:PCH_Pc21g09450; -.
DR eggNOG; KOG0238; Eukaryota.
DR HOGENOM; CLU_000395_3_1_1; -.
DR OMA; RDIRYET; -.
DR OrthoDB; 1459320at2759; -.
DR BioCyc; PCHR:PC21G09450-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 36..493
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 157..357
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 800 AA; 87769 MW; 94919A0F65E00988 CRC64;
MTMANTNKYE DTSNASPLRK PLFVAQPPLG SDGRQIIRKV LIANRGEIAC RIIKTCRVLN
ILSVAVYVDE DASSRHVRDA DEAINIGSID RSERNPFLDI DLLIRTAVSA GAQAIHPGYG
YLSENADFAN TVRKAGLIFV GPSASAMSTL GDKRSSKEYL RQQAPDVPLI PGFSGSSQDE
DALKQAAQEI GFPVMLKASA GGGGKGMRIV REAGELKQEL ARAQSEAQRS FGSSDCILEK
YIESSKHVEI QILGDSHGEV ISFFDRDCSV QRRHQKVIEE TPCTFLTDET RQNMSNTAVR
IAKLIGYENA GTVEFIVDIK TNHFYFLEVN ARLQVEHPIT EEVTQVDLVA LQLFVAASGK
LQSLPVVQNV TQKGHAIECR LCAEDPQKSF FPEHGKVHLW LPASGALGPG RDIRYETAIE
TGSTVSIYFD SMIAKIVVWA PTRPLAVEKM AKVLAHTACV GVKTNQLFLQ ACLLNKAFYD
PAYETSFIPT HIDELLQPYW SGDLQEVEKV LSVLPGLVVR KIPSFIPVGI QKKPFWGVRA
QFRNQRMDPV SVHCDIVTTV DWPGKKQEDI DFATTMCIWK PQIKQSSSSE AEAYLIPVEK
VGQSQEESAA AATQVSAQYN SISQALRSGK AMSSSPYRVS IDSWHPSQGN PAMVESWLAS
TIQLSIDGTK FLAHVALPSA KPHALVGEID RGQRVFCHLP ALGTYVEFKR DTLLSFAESI
RSVAKAKGGP EQRTIEAPMP CKVLSILKSN GEEVQSGESV MVIESMKMEV SIAVSVSGKF
ETRWKQGDAV EEGKILCSVV
//