ID B6HR54_PENRW Unreviewed; 1217 AA.
AC B6HR54;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Pc22g16480 protein {ECO:0000313|EMBL:CAP98936.1};
GN ORFNames=Pc22g16480 {ECO:0000313|EMBL:CAP98936.1}, PCH_Pc22g16480
GN {ECO:0000313|EMBL:CAP98936.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP98936.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP98936.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
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DR EMBL; AM920437; CAP98936.1; -; Genomic_DNA.
DR RefSeq; XP_002565563.1; XM_002565517.1.
DR AlphaFoldDB; B6HR54; -.
DR STRING; 500485.B6HR54; -.
DR GeneID; 8305202; -.
DR KEGG; pcs:Pc22g16480; -.
DR VEuPathDB; FungiDB:PCH_Pc22g16480; -.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_001251_6_0_1; -.
DR OMA; CFRQKII; -.
DR OrthoDB; 5100844at2759; -.
DR BioCyc; PCHR:PC22G16480-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 513..705
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 891..1189
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..157
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1217 AA; 137074 MW; 8D1B98E62BC2EA22 CRC64;
MADLGGQRSR NYRPHGPASS TQRDAAYSDI FGGAPPAGRS HTMNSQTPQF SQGRAHTMSS
HVVHPQFQRP PPPPTRQMPN GHGPPSAPPN GYPPPPPSGQ YQAYNPGASA TMSSHQLPRH
NPNTQQRFAA YPRPQRLESR PSPAPQYPDP RDFNRPMPPP ALNSDSTRSR SMAKLSGPPY
QTPPSNFNHT SATASRREQY HAGTQVTQLG RPVPEKHANE RAMSMTSWSS DRDPHIMNSG
RSIPYRRPPS SHDQQIPVRY DSMMQPGPDE FVASRQPSDA SQRSRTMSMA STVAPDRTMS
VQSQATQGTQ GSSGKATLVS RDSQRKVPVV YPAMLSLVAE VFREKISLGE RQKNGLSYQN
AFSGTDSVDL IASIIRTNDR NLALLLGRAL DAQKFFHDVT YDHRLRDAPG EVYQFKETMG
EDKSTIEVNG VFTLLTECYS PTCNRDTLCY SIACPRRLEQ QARLNLKPEP VLGTSESKTA
LPPDDDDDND NQKLWISTVP KEISDSVDDH EKKRQEIIFE VMYTERDFVK DLEYLRDFWM
RPLRAAGTTT HSPIPEHRRE KFIRTVFGNC LEVLKVNSAL CEALNARQKE SQVVHTIGDI
FCQHVPNFDP FIKYGANQLY GKYEFEKEKA SNPAFAKFVE DTERLKESRK LELNGYLTKP
TTRLARYPLL LEGVYKNSAD GNPDKEDIPK AIKLIKDFLS RVNAESGKAE NHFNLVQLNA
ALKFNSADYV DLKLTEENRQ MLMKMSFKKT TADSSDVTAY LFDHAVLLVR VKTVNKREES
RVYRKPIPLE LLVIAQMEEV IPRLGIAKRP SSSLLSNKAV INNPPPAKDG GLPITFRHLG
KGGYEQTLYA TSAATRRKFI EAVEQQQQKL WERNSNFYNK TILSEGFFAA VNRINCLVPI
DGGRKLVYGT DNGIFVSERW PKDKTAKPRK VLEATQVTQI DTLEEYQLLL VLANKTLSSY
PMDALDYVEG QNSMAKRPKK IQGHANFFKA GIGLGRHLVC SVKTSALSST IKVYEPMDNL
AKGKKKSAVS KMFQGGQDTL KPFKEYYIPA ESSSIHFLRS TLCVGCARGF EVVSLETTET
QSLLDQADTS LDFVARKENV KPIHIERMNG EFLLNYSDFS FFVNRNGWRA RPDWRIAWEG
NPNSFALSYP YILAFEPNFV EIRHVETSEL THLMTGKNIR MLHSSTREII YAYEDDRGYD
TVASLDFWTN KPQPAAV
//