ID B6HSS8_PENRW Unreviewed; 321 AA.
AC B6HSS8;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Pc22g13160 protein {ECO:0000313|EMBL:CAP98604.1};
GN ORFNames=Pc22g13160 {ECO:0000313|EMBL:CAP98604.1}, PCH_Pc22g13160
GN {ECO:0000313|EMBL:CAP98604.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP98604.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP98604.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
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DR EMBL; AM920437; CAP98604.1; -; Genomic_DNA.
DR RefSeq; XP_002565243.1; XM_002565197.1.
DR AlphaFoldDB; B6HSS8; -.
DR STRING; 500485.B6HSS8; -.
DR GeneID; 8310820; -.
DR KEGG; pcs:Pc22g13160; -.
DR VEuPathDB; FungiDB:PCH_Pc22g13160; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_6_1_1; -.
DR OMA; CSEAFDM; -.
DR OrthoDB; 203032at2759; -.
DR BioCyc; PCHR:PC22G13160-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR22981:SF81; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 7..175
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 181..303
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 185
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 321 AA; 34495 MW; D4C061F55402C259 CRC64;
MMQAKAIGFI GLGNMGFSMA TNLAEKLPVN SSVHVFDIIP ALVDDICAKY PDRVVACSGP
KDVADRSDII ITMLPEGKHV KAVYMGTDGI CSSDVGQKLL VDCSTIDTAS FLEIKDHISK
NFPRASFYDA PVSGGVIGAE RGMIAFFLGC AEDNTKDIEE LRQLFSLMGN KLIPCGGPSL
GIAAKLSNNY LSGIIAIACS EAMDMGMKSG LDPRVLAQVY AAGNAQNTIC DRFNPVPGVD
PDAPSSNGYK KGFKVHLMKK DISLALDMAH RVGSTNVLGS VGLQIYKEAS EDERCKDLDS
RIVFRYLGGN ENWKADHENK D
//
