ID B6JXT0_SCHJY Unreviewed; 519 AA.
AC B6JXT0;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Nucleolar GTP-binding protein 2 {ECO:0000256|ARBA:ARBA00022127, ECO:0000256|RuleBase:RU364023};
GN Name=nog2 {ECO:0000313|JaponicusDB:SJAG_01391};
GN ORFNames=SJAG_01391 {ECO:0000313|EMBL:EEB06348.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB06348.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB06348.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC nucleolus and is required for their nuclear export and maturation.
CC {ECO:0000256|ARBA:ARBA00003892, ECO:0000256|RuleBase:RU364023}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU364023}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC subfamily. {ECO:0000256|RuleBase:RU364023}.
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DR EMBL; KE651168; EEB06348.2; -; Genomic_DNA.
DR RefSeq; XP_002172641.2; XM_002172605.2.
DR AlphaFoldDB; B6JXT0; -.
DR STRING; 402676.B6JXT0; -.
DR EnsemblFungi; EEB06348; EEB06348; SJAG_01391.
DR GeneID; 7048140; -.
DR JaponicusDB; SJAG_01391; nog2.
DR VEuPathDB; FungiDB:SJAG_01391; -.
DR eggNOG; KOG2423; Eukaryota.
DR HOGENOM; CLU_011106_4_0_1; -.
DR OMA; KNPEDHI; -.
DR OrthoDB; 2879109at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01858; NGP_1; 1.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR024929; GNL2_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR012971; NOG2_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11089; GTP-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11089:SF9; NUCLEOLAR GTP-BINDING PROTEIN 2; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF08153; NGP1NT; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU364023};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364023};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT DOMAIN 206..367
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT REGION 464..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..499
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 57681 MW; C65E9684892C2D77 CRC64;
MGTFKKEKNR ITREGVNKKP GNLRVKGENF YRDAKDVAKV NMYRSGKAKY DAAGKIVKDA
AFQSKEVPKA RVQPDRRWFN NTRVISQDAL TQFREALGQA ENDPYQILLK RNKIPMSLLQ
ENSTIPKVRV IDSEPYDKTF GPGARRKRPK LAFSSIDELV AGSTDKQTAY EEKEEERFMM
NQDAYNGVST AVRDAIFSKG QSRRIWNELY KVIDSSDVLL QVLDARDPMG TRCRSVEKYL
KREAPHKHMV LVLNKIDLVP TSIAAAWTKI LGKEYPTIAF HASITNPFGK GSLIQLLRQF
SSLHSDKKQI SVGLIGYPNA GKSSVINTLR KKKVCTVAPI PGETKVWQYV SLMKRIFLID
CPGIVPPSAS DSDADLLLKG VVRVENVSNP EAYIPVVLSR CKQAHLERTY EISGWSDSNE
FLSMLAKKGG RLLKGGEADE AAVAKMVLND FMRGKIPWFV GPKGLSSAEP ARESEEVTEE
QEPSSESQAS EEEWTGIGED DDGSASAAAA SAAAVEVKE
//
