ID B6JY81_SCHJY Unreviewed; 729 AA.
AC B6JY81;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cullin 4 {ECO:0000313|EMBL:EEB06499.1};
GN Name=cul4 {ECO:0000313|JaponicusDB:SJAG_01540};
GN ORFNames=SJAG_01540 {ECO:0000313|EMBL:EEB06499.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB06499.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB06499.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; KE651168; EEB06499.1; -; Genomic_DNA.
DR RefSeq; XP_002172792.1; XM_002172756.2.
DR AlphaFoldDB; B6JY81; -.
DR STRING; 402676.B6JY81; -.
DR EnsemblFungi; EEB06499; EEB06499; SJAG_01540.
DR GeneID; 7048725; -.
DR JaponicusDB; SJAG_01540; cul4.
DR VEuPathDB; FungiDB:SJAG_01540; -.
DR eggNOG; KOG2167; Eukaryota.
DR HOGENOM; CLU_004747_7_0_1; -.
DR OMA; NYQEQTW; -.
DR OrthoDB; 5474206at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0043494; C:CLRC complex; IEA:EnsemblFungi.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:0033621; P:nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts; IEA:EnsemblFungi.
DR GO; GO:0031508; P:pericentric heterochromatin formation; IEA:EnsemblFungi.
DR GO; GO:0008104; P:protein localization; IEA:EnsemblFungi.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0031048; P:regulatory ncRNA-mediated heterochromatin formation; IEA:EnsemblFungi.
DR GO; GO:0030466; P:silent mating-type cassette heterochromatin formation; IEA:EnsemblFungi.
DR GO; GO:0031509; P:subtelomeric heterochromatin formation; IEA:EnsemblFungi.
DR GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; IEA:EnsemblFungi.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 374..602
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 729 AA; 84478 MW; ADB309C0426C57D3 CRC64;
MQGKVKKIVV RGFDPKKTKE RQENYYHDTL KKLDVALSVI MSGLGLNSGY QELYVGVQNL
VRAGQTESCL ELLLRHCQKG IAELKELALA SISTAVDESC KAVIHCWRQW TERIELIHNI
FYYMDRAYLI RVAGQTSILE FSVSLFRDDF MSFDEIRVPF LNQLTSLFEQ LRNGNNVDKT
LLKDASKMLQ QTHLFDKLFF PMYLCSLETN YTSASQAELQ KVPLDEFLLY IERCLKHEED
IVHEMFADNV LVDVNAVLDR CLVSQHISSM TPGLKDFVLK RKTDSCKSLY TLLKRVDETK
LLCDPWSQGI VALGSSLVND PNHDDSLISE LLEIHIFLKD VLKHAFLGDE ALSYSMRKSF
ETFLSSLPST RREKPAELLA KYIDHLMRST KSVVGNNTFD NVCAELLDIF RYLPNKDVFE
AFYKRDVAKR LLLNKSANTD NERKLLEMLK EKCGSTFTHS LEGMFKDVDF SKDFSKSFKE
SKFGRSLHYD LFVNVLSLAY WPTYPDTTIT LPPELETDLD IFKNFYLSQQ TARRLAWRPA
LCYCLLKAEF PSGSKELSVS LFQACVLLLF NDVGDEGLSY VDIQKRTQLN DNDLTRTLQS
LCCAHVRPLL MQPKSRRITK EHRFFYNQHF TNPHFRIKIN QIQLRESKEE KASVQEEVVR
DRQFELQACV VRLMKANKTM TYNQLVRQTM DYLQIRGKPD LSEVKKGIEK LIEKEYIERT
DDTNLAYVA
//
