ID B6JYS3_SCHJY Unreviewed; 1147 AA.
AC B6JYS3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Translation initiation factor eIF3 alpha subunit {ECO:0000313|EMBL:EEB06691.1};
GN Name=clu1 {ECO:0000313|JaponicusDB:SJAG_01741};
GN ORFNames=SJAG_01741 {ECO:0000313|EMBL:EEB06691.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB06691.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB06691.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
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DR EMBL; KE651168; EEB06691.1; -; Genomic_DNA.
DR RefSeq; XP_002172984.1; XM_002172948.2.
DR AlphaFoldDB; B6JYS3; -.
DR STRING; 402676.B6JYS3; -.
DR EnsemblFungi; EEB06691; EEB06691; SJAG_01741.
DR GeneID; 7049903; -.
DR JaponicusDB; SJAG_01741; clu1.
DR VEuPathDB; FungiDB:SJAG_01741; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR OMA; HPVWDKD; -.
DR OrthoDB; 927222at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 3.30.2280.10; Hypothetical protein (hspc210); 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601:SF6; CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR Pfam; PF13374; TPR_10; 2.
DR SUPFAM; SSF103107; Hypothetical protein c14orf129, hspc210; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51823; CLU; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000313|EMBL:EEB06691.1};
KW Protein biosynthesis {ECO:0000313|EMBL:EEB06691.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT DOMAIN 317..561
FT /note="Clu"
FT /evidence="ECO:0000259|PROSITE:PS51823"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 129436 MW; E3D458F3F2B12F68 CRC64;
MNEENRKTEG EHEEEKENKS AVSSAATVLE NEIKVTVDFG SDVAPLSLYA SPYDNFNDLR
QHVIELNNGL YTCFRLEYNG TIMNPFQELS EAIDCETVKE ISLRVILDHY TERESLYHAF
RLLDNIRSGC SRQSHNAELG ALMSVYPQLV RNQCGDVDAS RNTSHAQFKD FSGEQLSLQY
YVKLFEDAAQ ASEEIDCLQD FGLSAWNPVP PYWALQGHLF YLRVTVLEGQ QFHITSRYDG
YCVNQSSNTK FDPSPNPKYA LHHSLSALLS SLSPKFQAGL ADLLKSSGEL DQTLKLQVSK
VLQQPTWINT HSVYTADITR TQSIVCNPFL ENKSNLRDWN DEIQSVREMP YANLQERVLR
ERLLQKTLNE FTESAMAGAI EVVNGNVPAL NPTEPLASQM YIHNNIFFSY GMDSIGIFDK
TGGNEASRHA VGKDVAYIRL LTQSDRCPIS LLGTCLIDFA GHRIVAQTLI PGIFRQQDEG
ATQVVYGKVD GEDTFVFDKK LDPLLKEVSA ILHLKKHPVV GNDGKTISMF TSMDAKGLKG
TDGRSYLLDL YSLFPLDIGF LEEIANDDSK LPAYPHTLAY LRPELIQSIW ETKLKNYAEA
KAAKLKESVP KDELEKIPDI SLNDFDYTLN PDVFRSDYKV PKDYEQTLKK DEEAVKAVSE
LLRNDIIPSF VKTVCTDESA MPVDGIALAR MMHKRGINMR YLGKVAELAA SQYGNDHPLV
YLAELEMLAR AVKHVFSNNI AKHSFYNRAS SVAYLLCCIF SEDEAFKDSP VYKEYLQKIP
SESFQTPTQV KESVAQNVAS RFRYRIHNSA KFVKSPPLLR NICLKLGIQL LCRDYFCEPF
VPAALQPATA GDKKSKKKKA TKKKPSQTTF EPVLFYPTDI LNILPLIKTC TPCSTLAREA
FDACKLSIAQ KDKNVSLSLL SESLMLHEQI YGILHAEVAR AYCQVALLFY QLEDKEQALN
LARKAVLVCE RVLGFDSAET ILGYMNLSLY EFSSGNIAIA LAFCVHALKL WRCIFGPEHP
DMITSFNNVA VMVQRMNNFV DSQKWFQASV DLSKKFFGNT LNTASLYFQL AQSMAFNDES
RNALKAIRIA YDIYKEELGE DHATTKEAEE WLSKFTANAV YHAKHLKIQQ LQPHGEASAL
RTHRFSS
//
