ID B6K2Z3_SCHJY Unreviewed; 428 AA.
AC B6K2Z3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Homocysteine synthase Met17 {ECO:0000313|EMBL:EEB07850.1};
GN Name=met17 {ECO:0000313|JaponicusDB:SJAG_02972};
GN ORFNames=SJAG_02972 {ECO:0000313|EMBL:EEB07850.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB07850.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB07850.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; KE651167; EEB07850.1; -; Genomic_DNA.
DR RefSeq; XP_002174143.1; XM_002174107.2.
DR AlphaFoldDB; B6K2Z3; -.
DR STRING; 402676.B6K2Z3; -.
DR EnsemblFungi; EEB07850; EEB07850; SJAG_02972.
DR GeneID; 7051744; -.
DR JaponicusDB; SJAG_02972; met17.
DR VEuPathDB; FungiDB:SJAG_02972; -.
DR eggNOG; KOG0053; Eukaryota.
DR HOGENOM; CLU_018986_4_0_1; -.
DR OMA; NAFQIIQ; -.
DR OrthoDB; 6018at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0004124; F:cysteine synthase activity; IEA:EnsemblFungi.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:EnsemblFungi.
DR GO; GO:0071269; P:L-homocysteine biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0000103; P:sulfate assimilation; IEA:EnsemblFungi.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT MOD_RES 209
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 428 AA; 45919 MW; 1C1A4CC607F84434 CRC64;
MVESKHFETL QLHAGQEVDP TTRSRAVPIY ATTSYVFRDS DHGGRLFGLQ EGGYIYSRMN
NPTSDVFEKR MAALENGAAA VATSSGQSAI FMALTTLAAA GDNIVSTSFL YGGTYNLFNT
TLPRLGITTK FVEGDNADDL AAAIDDNTKA VYVESIGNPK YNVPDLEKIA KIAHAAGVPL
VVDNTFGGGG YLIRPIDHGA DIVCHSATKW IGGHGTTVGG VMVDSGKFDW VKNAKRFPQF
VEPSPGYHGM VFSEAFGNVA FAAAFRTLSL RDLGGNANPF GTFLLIQGLE TLSLRMERHV
SNALALAKYL EKHPQVAWVS YPGLASHPSH EIAKKYLKNG FGAMLSFGVK GGADASKKTV
NRLKLASQLA NVGDAKTLVI APAYTTHLQL TDEEQLSAGV TKDLIRVAVG IEHIDDIVAD
FEQALQFE
//
