ID B6K4R7_SCHJY Unreviewed; 307 AA.
AC B6K4R7;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Translation initiation factor eIF2 alpha subunit {ECO:0000313|EMBL:EEB08474.1};
GN Name=tif211 {ECO:0000313|JaponicusDB:SJAG_03629};
GN ORFNames=SJAG_03629 {ECO:0000313|EMBL:EEB08474.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08474.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB08474.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family.
CC {ECO:0000256|ARBA:ARBA00007223}.
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DR EMBL; KE651167; EEB08474.1; -; Genomic_DNA.
DR RefSeq; XP_002174767.1; XM_002174731.2.
DR AlphaFoldDB; B6K4R7; -.
DR STRING; 402676.B6K4R7; -.
DR EnsemblFungi; EEB08474; EEB08474; SJAG_03629.
DR GeneID; 7051337; -.
DR JaponicusDB; SJAG_03629; tif211.
DR VEuPathDB; FungiDB:SJAG_03629; -.
DR eggNOG; KOG2916; Eukaryota.
DR HOGENOM; CLU_033458_0_1_1; -.
DR OMA; DVNEHQR; -.
DR OrthoDB; 4371132at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IBA:GO_Central.
DR GO; GO:0005850; C:eukaryotic translation initiation factor 2 complex; IBA:GO_Central.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0005840; C:ribosome; IEA:EnsemblFungi.
DR GO; GO:0005525; F:GTP binding; IEA:EnsemblFungi.
DR GO; GO:1990856; F:methionyl-initiator methionine tRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IEA:EnsemblFungi.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 3.30.70.1130; EIF_2_alpha; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR PANTHER; PTHR10602:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; eIF-2-alpha, C-terminal domain; 1.
DR SUPFAM; SSF116742; eIF2alpha middle domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EEB08474.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT DOMAIN 17..88
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 307 AA; 34601 MW; 2C1C459D39F97210 CRC64;
MSTTSCRMYE NRFPEVDELV VVNVRQIQEM GAYVKLLEYD NIEGMVLLSE LSRRRIRSVQ
KHIRVGRNEV VVVLRVDKEK GYIDLSKRRV SPEDVLKCEE RFNKSKAVHS IMRHIAEKHN
VPLETMYTSI GWPLYRKYGH AYDAFKLAIT SPEVVFEGLD EPAPGVVKDL LAQISRRLTP
QPIKIRADVE VTCFGYDGIT AIKNALRAAE AVHTEDIPVK VKLVAPPLYV ILTNALDKTL
GVKKLEEAIA AIEKSITEAN GSCVVKMKPK AVSETDELEL ADLMKKFEKE NAEISGDEED
DDQSGSE
//
