ID   B6K5D6_SCHJY            Unreviewed;       685 AA.
AC   B6K5D6;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Long-chain-fatty-acid-CoA ligase {ECO:0000313|EMBL:EEB08740.1};
GN   Name=lcf2 {ECO:0000313|JaponicusDB:SJAG_03909};
GN   ORFNames=SJAG_03909 {ECO:0000313|EMBL:EEB08740.1};
OS   Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08740.1, ECO:0000313|Proteomes:UP000001744};
RN   [1] {ECO:0000313|EMBL:EEB08740.1, ECO:0000313|Proteomes:UP000001744}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
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DR   EMBL; KE651167; EEB08740.1; -; Genomic_DNA.
DR   RefSeq; XP_002175033.1; XM_002174997.2.
DR   AlphaFoldDB; B6K5D6; -.
DR   STRING; 402676.B6K5D6; -.
DR   EnsemblFungi; EEB08740; EEB08740; SJAG_03909.
DR   GeneID; 7050543; -.
DR   JaponicusDB; SJAG_03909; lcf2.
DR   VEuPathDB; FungiDB:SJAG_03909; -.
DR   eggNOG; KOG1180; Eukaryota.
DR   HOGENOM; CLU_000022_45_2_1; -.
DR   OMA; HIFEFIF; -.
DR   OrthoDB; 443463at2759; -.
DR   Proteomes; UP000001744; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IBA:GO_Central.
DR   GO; GO:0090432; F:myristoyl-CoA ligase activity; IEA:EnsemblFungi.
DR   GO; GO:0001676; P:long-chain fatty acid metabolic process; IBA:GO_Central.
DR   GO; GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43272:SF97; LONG-CHAIN-FATTY-ACID--COA LIGASE 2; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:EEB08740.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT   DOMAIN          89..503
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   685 AA;  75830 MW;  42E0867429DD1762 CRC64;
     MKELFSVETT EPRKPGETHV YRSVHSAKGL LERPEEGINT VYDVLKRAIT AHGNKDAMGW
     RKRIKTHVEE REVVKKIGDR EVKEKKHWIL YELGPYQYIS FTRVYELACA AGAGLRQLNF
     QAGDRLLLFA TTSSSWFLTA QGCVTQSVPI VTAYETLGEP GLITSVSESK PRAIFTDPGL
     LSKLIVPLKD APFVETILCS SQPTEEQTAA LKAVAPQLKF ITFDELIATG EKNPCEVVPP
     APSDVCVYMY TSGSTGKPKG VMLLHRNIVS VIAGINRILS HHINEKDYVM AYLPLAHVFE
     FFFEMCCLYW GGVLGYGSVR TLNDASVKNC RGDLAEFRPS VLIGVPAVFE ALRKGIMAKV
     SQMPIHRQKI FSGALSLKQY LMGKNLPGTE LLDALVFNKI KAATGGRIRY CINGGAALAP
     TTQAFISAAI APVLLGYGLT ETCAGSFVLS PEAFYLFSRS VGAPIPCVEF KLVDIPELNY
     LTSQNPPRGE VWIRGPSVCG GYFNRTDATQ EVFTEDGWFK TGDVGELDEN NMLCLIDRKK
     NIVKSLNGEY IALEKLETQF NTSKLILNIC VYADTQHYKP VCIVVPAEGP LREQLKSVQG
     KEFFGNPDES LSALCKDPQV RSVVLADLIS IAKQRKFATI ETPQSVVLVD DEWTPDNDLL
     TPSRKLKRQN IVARYNDLIM EAYGN
//