ID B6K5M1_SCHJY Unreviewed; 992 AA.
AC B6K5M1;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Histone demethylase SWIRM1 {ECO:0000313|EMBL:EEB08825.2};
GN Name=lsd1 {ECO:0000313|JaponicusDB:SJAG_03997};
GN ORFNames=SJAG_03997 {ECO:0000313|EMBL:EEB08825.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08825.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB08825.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KE651167; EEB08825.2; -; Genomic_DNA.
DR RefSeq; XP_002175118.2; XM_002175082.2.
DR AlphaFoldDB; B6K5M1; -.
DR STRING; 402676.B6K5M1; -.
DR EnsemblFungi; EEB08825; EEB08825; SJAG_03997.
DR GeneID; 7051611; -.
DR JaponicusDB; SJAG_03997; lsd1.
DR VEuPathDB; FungiDB:SJAG_03997; -.
DR eggNOG; KOG0029; Eukaryota.
DR HOGENOM; CLU_004498_1_2_1; -.
DR OMA; KTQWHVC; -.
DR OrthoDB; 5402444at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0033193; C:Lsd1/2 complex; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0140683; F:histone H3K9me/H3K9me2 demethylase activity; IEA:EnsemblFungi.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0033696; P:heterochromatin boundary formation; IEA:EnsemblFungi.
DR GO; GO:0071515; P:mating-type locus imprinting; IEA:EnsemblFungi.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:1902681; P:regulation of replication fork arrest at rDNA repeats; IEA:EnsemblFungi.
DR GO; GO:0011000; P:replication fork arrest at mating type locus; IEA:EnsemblFungi.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF386; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF04433; SWIRM; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS50934; SWIRM; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Methyltransferase {ECO:0000313|EMBL:EEB08825.2};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Transferase {ECO:0000313|EMBL:EEB08825.2}.
FT DOMAIN 133..229
FT /note="SWIRM"
FT /evidence="ECO:0000259|PROSITE:PS50934"
FT DOMAIN 823..904
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 823..904
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 51..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..985
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 111272 MW; 42984FB0CBBD59DB CRC64;
MYNPESFNND KMLRLPSQDN SDQALWAIFG RNEDLTPQTN GVVRAQANSL DLSQEEQTGH
ADTSTATDNL NKNADNYLQP GPSFLIASQL SSQTNKTTNS MTRYGARYVS AEAPISVKAS
VPSLPRVTYD RLCKEAALSC GLPSDALHPY EAKMLGEILE TSSWLTKYVD IRNGLCYLWI
RNPTLFISFT EALGIVREKD TFPLASLAFE FLTRNGYVNY GCLYIPFTVP YNETLPQKSV
AVVGCGLAGL SCARQLANLF AQYEQDFVNR NENVPRLVVF EADSRIGGRI LSHRLESSQT
NADVEKTSST DEEPTQHFIE IGADRILEMN NAMDPLRIVA DQQLSLDVQI HETPLVKLIS
EDGSSVDPAT IQRICELFDC VVFAVTLSND KITLNGVLTP EEQSLRERLD FLQRFGYHLS
LEHFRFSNEG SLGSTLKRAL SILNDFIQFN DVELQVLNWC LNYLQQGVGA NLDFVSTKCW
SCHYQPICQL SNSMTIGEGM SSIVQHMAST PTPLPIQLNH SVVSVKYNDT GVQLISSNQQ
VINVDKVVLC LPLSVYKKHT LTFEPALPDW KVTSLNRVST SNFRKVNLLF SHAFWDSEAT
VFGKVLGNSF NDIPMQSLIF FNYFKQTGLP LLITNYFASE NESDSEISEK VMNALTDQFS
HMQNFVRPKS VFISNWNTLP FSSGSLSVAT SSFSAADYKA LAAPLENTVF FASDSMSGES
LGTLHSSFRS GLMAARDVLA SLVGDVAIPQ TLIVNQASKQ TNTTTQSSNT SSTRRNTRSR
EQVTPKFSYR SEYIKAKQAR LEKENQECQM LIQELLGAPP EMPSRPTANP FLLYQKTQWH
VCKAMADKDR QEATGDPEAR ATKNEIRAKL GRSWRDLDES GKQPWIDEVN ARRANYTALM
EEYQRQLNTF NTRAAQIKAE HRRKCEAQPI PVEESRLQAL AENEEEERAR NEPPSTNSHM
SNVYDESDDE YHDEGEDEDD DVADDLYSNG YL
//