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Database: UniProt
Entry: B6K5M1_SCHJY
LinkDB: B6K5M1_SCHJY
Original site: B6K5M1_SCHJY 
ID   B6K5M1_SCHJY            Unreviewed;       992 AA.
AC   B6K5M1;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 2.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=Histone demethylase SWIRM1 {ECO:0000313|EMBL:EEB08825.2};
GN   Name=lsd1 {ECO:0000313|JaponicusDB:SJAG_03997};
GN   ORFNames=SJAG_03997 {ECO:0000313|EMBL:EEB08825.2};
OS   Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08825.2, ECO:0000313|Proteomes:UP000001744};
RN   [1] {ECO:0000313|EMBL:EEB08825.2, ECO:0000313|Proteomes:UP000001744}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; KE651167; EEB08825.2; -; Genomic_DNA.
DR   RefSeq; XP_002175118.2; XM_002175082.2.
DR   AlphaFoldDB; B6K5M1; -.
DR   STRING; 402676.B6K5M1; -.
DR   EnsemblFungi; EEB08825; EEB08825; SJAG_03997.
DR   GeneID; 7051611; -.
DR   JaponicusDB; SJAG_03997; lsd1.
DR   VEuPathDB; FungiDB:SJAG_03997; -.
DR   eggNOG; KOG0029; Eukaryota.
DR   HOGENOM; CLU_004498_1_2_1; -.
DR   OMA; KTQWHVC; -.
DR   OrthoDB; 5402444at2759; -.
DR   Proteomes; UP000001744; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0033193; C:Lsd1/2 complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0140683; F:histone H3K9me/H3K9me2 demethylase activity; IEA:EnsemblFungi.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0033696; P:heterochromatin boundary formation; IEA:EnsemblFungi.
DR   GO; GO:0071515; P:mating-type locus imprinting; IEA:EnsemblFungi.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:1902681; P:regulation of replication fork arrest at rDNA repeats; IEA:EnsemblFungi.
DR   GO; GO:0011000; P:replication fork arrest at mating type locus; IEA:EnsemblFungi.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR007526; SWIRM.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR   PANTHER; PTHR10742:SF386; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF04433; SWIRM; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS50934; SWIRM; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Methyltransferase {ECO:0000313|EMBL:EEB08825.2};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW   Transferase {ECO:0000313|EMBL:EEB08825.2}.
FT   DOMAIN          133..229
FT                   /note="SWIRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50934"
FT   DOMAIN          823..904
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        823..904
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          51..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          759..784
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          922..992
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        938..953
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        967..985
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   992 AA;  111272 MW;  42984FB0CBBD59DB CRC64;
     MYNPESFNND KMLRLPSQDN SDQALWAIFG RNEDLTPQTN GVVRAQANSL DLSQEEQTGH
     ADTSTATDNL NKNADNYLQP GPSFLIASQL SSQTNKTTNS MTRYGARYVS AEAPISVKAS
     VPSLPRVTYD RLCKEAALSC GLPSDALHPY EAKMLGEILE TSSWLTKYVD IRNGLCYLWI
     RNPTLFISFT EALGIVREKD TFPLASLAFE FLTRNGYVNY GCLYIPFTVP YNETLPQKSV
     AVVGCGLAGL SCARQLANLF AQYEQDFVNR NENVPRLVVF EADSRIGGRI LSHRLESSQT
     NADVEKTSST DEEPTQHFIE IGADRILEMN NAMDPLRIVA DQQLSLDVQI HETPLVKLIS
     EDGSSVDPAT IQRICELFDC VVFAVTLSND KITLNGVLTP EEQSLRERLD FLQRFGYHLS
     LEHFRFSNEG SLGSTLKRAL SILNDFIQFN DVELQVLNWC LNYLQQGVGA NLDFVSTKCW
     SCHYQPICQL SNSMTIGEGM SSIVQHMAST PTPLPIQLNH SVVSVKYNDT GVQLISSNQQ
     VINVDKVVLC LPLSVYKKHT LTFEPALPDW KVTSLNRVST SNFRKVNLLF SHAFWDSEAT
     VFGKVLGNSF NDIPMQSLIF FNYFKQTGLP LLITNYFASE NESDSEISEK VMNALTDQFS
     HMQNFVRPKS VFISNWNTLP FSSGSLSVAT SSFSAADYKA LAAPLENTVF FASDSMSGES
     LGTLHSSFRS GLMAARDVLA SLVGDVAIPQ TLIVNQASKQ TNTTTQSSNT SSTRRNTRSR
     EQVTPKFSYR SEYIKAKQAR LEKENQECQM LIQELLGAPP EMPSRPTANP FLLYQKTQWH
     VCKAMADKDR QEATGDPEAR ATKNEIRAKL GRSWRDLDES GKQPWIDEVN ARRANYTALM
     EEYQRQLNTF NTRAAQIKAE HRRKCEAQPI PVEESRLQAL AENEEEERAR NEPPSTNSHM
     SNVYDESDDE YHDEGEDEDD DVADDLYSNG YL
//
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