GenomeNet

Database: UniProt
Entry: B6KJX9_TOXGV
LinkDB: B6KJX9_TOXGV
Original site: B6KJX9_TOXGV 
ID   B6KJX9_TOXGV            Unreviewed;       909 AA.
AC   B6KJX9; A0A0F7V4B0; A0A0N5E8W8; B9Q4L4; S8GK16;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   15-FEB-2017, entry version 42.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=BN1205_022810 {ECO:0000313|EMBL:CEL74960.1}, TGVEG_232830
GN   {ECO:0000313|EMBL:ESS35787.1};
OS   Toxoplasma gondii (strain ATCC 50861 / VEG).
OC   Eukaryota; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS35787.1, ECO:0000313|Proteomes:UP000002226};
RN   [1] {ECO:0000313|EMBL:ESS35787.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=VEG {ECO:0000313|EMBL:ESS35787.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA   Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT   "Annotation of Toxoplasma gondii VEG.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ESS35787.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=VEG {ECO:0000313|EMBL:ESS35787.1};
RA   Gandolfi B., Grahn R.A.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CEL74960.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=VEG {ECO:0000313|EMBL:CEL74960.1};
RX   PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA   Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E.,
RA   Panigrahi A., Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT   "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora
RT   caninum LIV Genomes with Tachyzoite Stage Transcriptome and Proteome
RT   Defines Novel Transcript Features.";
RL   PLoS ONE 10:e0124473-e0124473(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; LN714498; CEL74960.1; -; Genomic_DNA.
DR   EMBL; AAYL02000019; ESS35787.1; -; Genomic_DNA.
DR   STRING; 5811.TGME49_032830; -.
DR   EnsemblProtists; ESS35787; ESS35787; TGVEG_232830.
DR   EuPathDB; ToxoDB:TGME49_232830; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; B6KJX9; -.
DR   Proteomes; UP000002226; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002226};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    457    481       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    502    519       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    581    598       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    610    634       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    676    695       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    843    868       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       50     77       {ECO:0000256|SAM:Coils}.
FT   COILED      100    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   909 AA;  101077 MW;  399190C60F665B78 CRC64;
     MTTLRSEPML RGTLVLPSAL PLAHGCLEAL GRQGSVHFLD MNAHSLTRQF NTYIQRIDEM
     ERIIRFLEEE VNRLQDAGAK IIVGPEGAQN FLDNDKSYQL DKVEEALNRL HAQFVRFKSN
     NADLIQQKNA ALEEKCVMTT AVQQLQGSAM KDGFSAGAQN SPADGTAAGN SEEEVAKALL
     RQDDNKDMTP NADDPEAGLT KTEGGSSGSS VSTVAGMIAT SAIGRFQRML FRTTRGNAFC
     FFQSTAEKLV DSNTGNEVEK GVFVIYYQGA AHSLLREKIV KVCAAFDAKP YEWPHSAEEA
     ATRLAGLQSL LDDKERALAA YEKYFLSEIS LLLEVTRPGG SSLLEEWKMF CQKEKAVYAT
     LNQFQGKDMT LRCDCWIPRD KEEEIRSILK DVSTDPNGEE QASAFLLIEK GQPTAMPPTY
     FKTTEFTEPS QVMVDTYGVP RYQEANPAVL TTITFPFLFG VMYGDIGHGL CVMLMGLWLL
     FRANALKQDR TAALHGAVKY RYMVFLMGFF AFFGGFMYND WFALGLDIFG SRWTLKGAEA
     GSSSITMRKK DGEFPYPFGF DPAWKGATNE LLFTNSFKMK FSVIVGFAQM FAGVLLKGSN
     AIFFREPLDF VFEFIPQVMF ICSLVGYMDF LILYKWATPA DQNKPNLINT IINMCMLAEV
     KSEDEMFSNQ QTVERILLVF MVISIPLMLI PKPLILCSRL KKNHPPGAHK ERLSSGKTNS
     STIELEHAPS GGANGAGAAA AVGDGNENSA IEAGLRKQGT TEEREGNVLS VIKEEIGEEH
     EGPGDIFIHQ MIETIEFILG TISNTASYLR LWALSLAHQQ LALVFYTQTV VRAIELTDNT
     TFVALALFVI FAAYACITFA VILCMDFLEV SLHALRLQWV EFQNKFFKGD GYKFAPLYFI
     KLLQGEDDA
//
DBGET integrated database retrieval system