ID   B6QMU2_TALMQ            Unreviewed;      1325 AA.
AC   B6QMU2;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=5-oxoprolinase, putative {ECO:0000313|EMBL:EEA22311.1};
GN   ORFNames=PMAA_060900 {ECO:0000313|EMBL:EEA22311.1};
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA22311.1, ECO:0000313|Proteomes:UP000001294};
RN   [1] {ECO:0000313|Proteomes:UP000001294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC   {ECO:0000313|Proteomes:UP000001294};
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; DS995903; EEA22311.1; -; Genomic_DNA.
DR   RefSeq; XP_002150920.1; XM_002150884.1.
DR   STRING; 441960.B6QMU2; -.
DR   VEuPathDB; FungiDB:PMAA_060900; -.
DR   HOGENOM; CLU_002157_0_1_1; -.
DR   OrthoDB; 674at2759; -.
DR   PhylomeDB; B6QMU2; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001294}.
FT   DOMAIN          16..235
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          255..550
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          562..739
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          757..1289
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1325 AA;  143675 MW;  9520BD79487BD854 CRC64;
     MAPHRLEANV DGLNIKIAID RGGTFTDCLG IVEGREDDIV VKLLSQDPSN YADAPIEGIR
     RILEQATGKP FPRSEKLSTG DFSSVSIRMG TTVATNALLE RKGDRVALLI TKGFKDALEI
     GNQSRPHLFD LNIRRPDVLY EEVVEVDERV TIEDYQQNPT PNKEALAASL DSDPQLTRGV
     SGEVVRVLEK LDEDKVRKDL QSLYEKGYRS IAVVLVHSYT FQDHELAIER IAKEVGFPSI
     SLSSQLLPMI KMTSRGASAT ADAYLTPVIR RYIDGFRSGF KDGLRSEDTR CEFMQSDGGL
     VNFEKFSGLR AILSGPAGGV VGHARTSFDP ADPRPVIGFD MGGTSTDVSR YDGKFEHTFE
     NTTAGVTIMA PQLDINTVAA GGGSVLFWRH GLFVVGPDSA GAHPGPACYR KGGPLTVTDA
     NLFLGRLLPE YFPKIFGPNE NEALDVEITR QKFTELARQI QEETGQAKSP EEIALGFIEV
     ANESMAKPIR ALTEARGYET SAHNLACFGG AGGQHACAIA TSLSIQTVII HRYSSILSAY
     GMALADVVHE AQEPASGFLD EQSLKTLRDR IQALKTKVQS ELEADGIPTE QIHHEVYLNL
     RYQGTDNLLM ILDPEDGDFA EAFIREHKRE FSFTFPGRPI VVEDVRVRGV GKSLSVAPEA
     PQAELKATKA ISIGTEKQDA STAVYFTGVG HVTTPVFFLG NLQPGSHING PAMIIDKTQT
     IVVEPHANAT ILSRHVILDV SPQKKRAAGE ESTLVVDPIR LSVFGYRFMS VADQMSRMFQ
     KTSVSTNIKE RLDFSCAVFS PDGKLVANAP NVPVHLGSME YAVRYQHEQF ADKLQPGDHI
     CTNHPLAGGT HLPDITIITP VWDAEGKQII FYVASRGHHA EIGGIQPGSM PSNSRLLYEE
     GAMTMGFKIV SEDRFNEDIV RKFLYDEPAS FPGCSGTRTW NDNVSDLKAA IAANQKGATL
     LRGLVEENSL QVVHFYMDGI KDNAEVAVRE YLKKVGKQTG GKPLKFSDFM DDGTEIRLEI
     RIDTETGSAD FDFTGTGRET FNCLNAPKAI AHSAIIYSLR CLINVDIPLN QGCLAPCNVI
     IPSGTLLNPS GNAAVCAGNP ITSQRITDVV LGAFNACAAS QGCCNIISFG MGGMDKDGNV
     VPGFGVGETI CGGSGAGPGW NGTSAVHCHM TNTRITDAEV YELRYPVILR QFSIRQGSGG
     RGQYNGGNGS VRELEFRIPL SVSMLSERRV YRPYGMAGGE PGQAGLNLYV RKEHDGSERT
     INIGGKMELN VQPGERIIIN SPGGGAWGSL SDAPEVAPGN TAWRPNVFEP RGSVHAFTAM
     AEAAQ
//