ID B6THE1_MAIZE Unreviewed; 312 AA.
AC B6THE1;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Aldose reductase {ECO:0000313|EMBL:ACG36524.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ACG36524.1};
RN [1] {ECO:0000313|EMBL:ACG36524.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18937034; DOI=10.1007/s11103-008-9415-4;
RA Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V.,
RA Zhang H., Swaller T.J., Lu Y.P., Bouck J., Flavell R.B., Feldmann K.A.;
RT "Insights into corn genes derived from large-scale cDNA sequencing.";
RL Plant Mol. Biol. 69:179-194(2009).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC {ECO:0000256|ARBA:ARBA00007905}.
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DR EMBL; EU964406; ACG36524.1; -; mRNA.
DR AlphaFoldDB; B6THE1; -.
DR ExpressionAtlas; B6THE1; baseline and differential.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19125; AKR_AKR4C1-15; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044498; AKR4C.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732:SF252; ALDO-KETO REDUCTASE FAMILY 4 MEMBER C9; 1.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 17..283
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 49
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 111
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 78
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 312 AA; 34411 MW; B285188110144F80 CRC64;
MAESFVLNTG SRIPSVGLGV WQIQPDAAND AIYAAVKAGY RHIDCAAAYN NEKEVGLALK
KLFEDGVVKR DDLFITSKLW AANHAPEDVE EGIDTTLQDL QLDYLDLYLI HGPIRIKKGT
STMTPENFLP TDIPATWAAM EKLYDSGKAR AIGVSNFSCK KLHDLLAVAR VPPAVNQVEC
HPVWQQDKLR KLCQSNGVHL SAFSPLGSPG SPWINGPSVL KNPIVVSVAD KLQKTPAQVA
LRWGIQMGHS VLPKSANESR IKENIDIFGW SIPEDLMAKF SEIKQVRLLT AEFVVHPQAG
YNTLEDFWDG EI
//