ID B6UXS3_DROYA Unreviewed; 633 AA.
AC B6UXS3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=RAD50 {ECO:0000313|EMBL:ACI97306.1};
DE Flags: Fragment;
GN Name=rad50 {ECO:0000313|EMBL:ACI97306.1};
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245 {ECO:0000313|EMBL:ACI97306.1};
RN [1] {ECO:0000313|EMBL:ACI97306.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yak {ECO:0000313|EMBL:ACI97306.1};
RX PubMed=18984573; DOI=10.1534/genetics.108.093807;
RA Anderson J.A., Gilliland W.D., Langley C.H.;
RT "Molecular population genetics and evolution of Drosophila meiosis genes.";
RL Genetics 181:177-185(2009).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; FJ219321; ACI97306.1; -; Genomic_DNA.
DR AlphaFoldDB; B6UXS3; -.
DR EnsemblMetazoa; FBtr0405992; FBpp0364595; FBgn0231806.
DR GO; GO:0000793; C:condensed chromosome; IEA:EnsemblMetazoa.
DR GO; GO:0030870; C:Mre11 complex; IEA:EnsemblMetazoa.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:EnsemblMetazoa.
DR GO; GO:0008104; P:protein localization; IEA:EnsemblMetazoa.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblMetazoa.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..231
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 423..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 165..230
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 559..614
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 427..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACI97306.1"
FT NON_TER 633
FT /evidence="ECO:0000313|EMBL:ACI97306.1"
SQ SEQUENCE 633 AA; 73038 MW; B6D9389F90208049 CRC64;
IKFSSPVTLI LGENGCGKTT VVECLKYALT GECPPGSDRG KSFVHDPKIF GLNEVLAQIK
MQVRDRRGAQ VSICRTMKVS KKRNKMSFET MDSTINFLTG AGQSKREKQD SLSGRSVDID
VAISDFMGVS KAIINNVLFC HQEDSSWPLD ESKKLKEKFD AIFGITEYNK ALDKIIKLRK
EAMEELKVKE ANMKHVAYLK QEMEVKTLNL QQAQRKCDAI KAQCSECEEE MKPIEARLME
IRNVEFEIGK YQAQKVEMDT KHKNCKDQIS TLTGKIKNLF GGTLAELDQE ISNFDQRMQE
VHQKRTVVEG DLSQIKRSKV SEQEKLGTQD RKHCLAKQRH QSELACRAQL LKRVKDFCRE
VHITINCDLV EQPEKMGEVL QDIEAMIITK HCEITEIVEQ NEKADRSRQV KIDELRIELT
KSEQSVTAQE KQRESSKRES DTIGEQIKKI ETSMQDLKKL EKEINDVNEL YESANKDIDQ
QAIKDAIARQ KASIAQNQIQ FKKLDEQLTF LGTMAKLVAE ISLKQKELDK KNQEVHRVRS
RHSDNFGKFF KEPITCNYRR SMQGVYDKLR REIQDLNEKA NSQKLKEQSF EIKRKNLIGD
ISQMEKELNM SEELIFEKCR STPYEDLLER SKT
//
