ID B6UYT2_KLEPN Unreviewed; 190 AA.
AC B6UYT2;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=R46 site-specific recombinase {ECO:0000313|EMBL:ACI63056.1};
DE SubName: Full=TnpR {ECO:0000313|EMBL:CAG29014.2};
GN Name=tnpR {ECO:0000313|EMBL:CAG29014.2};
OS Klebsiella pneumoniae.
OG Plasmid 12 {ECO:0000313|EMBL:ACI63056.1}, and
OG Plasmid pCC416 {ECO:0000313|EMBL:CAG29014.2}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573 {ECO:0000313|EMBL:ACI63056.1};
RN [1] {ECO:0000313|EMBL:CAG29014.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VA-416 /02 {ECO:0000313|EMBL:CAG29014.2};
RC PLASMID=pCC416 {ECO:0000313|EMBL:CAG29014.2};
RX PubMed=17540674; DOI=10.1093/jac/dkm171;
RA Colinon C., Miriagou V., Carattoli A., Luzzaro F., Rossolini G.M.;
RT "Characterization of the IncA/C plasmid pCC416 encoding VIM-4 and CMY-4
RT beta-lactamases.";
RL J. Antimicrob. Chemother. 60:258-262(2007).
RN [2] {ECO:0000313|EMBL:ACI63056.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=12 {ECO:0000313|EMBL:ACI63056.1};
RC PLASMID=12 {ECO:0000313|EMBL:ACI63056.1};
RX PubMed=19258268; DOI=10.1128/AAC.01355-08;
RA Gootz T.D., Lescoe M.K., Dib-Hajj F., Dougherty B.A., He W.,
RA Della-Latta P., Huard R.C.;
RT "Genetic organization of transposase regions surrounding blaKPC
RT carbapenemase genes on plasmids from Klebsiella strains isolated in a New
RT York City hospital.";
RL Antimicrob. Agents Chemother. 53:1998-2004(2009).
CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC {ECO:0000256|ARBA:ARBA00009913}.
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DR EMBL; FJ223605; ACI63056.1; -; Genomic_DNA.
DR EMBL; AJ704863; CAG29014.2; -; Genomic_DNA.
DR RefSeq; WP_001556711.1; NZ_WVSZ01000057.1.
DR RefSeq; YP_002286998.1; NC_011385.1.
DR GeneID; 83701906; -.
DR PATRIC; fig|573.1572.peg.5107; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR CDD; cd03768; SR_ResInv; 1.
DR Gene3D; 6.10.250.10; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006118; Recombinase_CS.
DR InterPro; IPR006119; Resolv_N.
DR InterPro; IPR036162; Resolvase-like_N_sf.
DR InterPro; IPR006120; Resolvase_HTH_dom.
DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1.
DR PANTHER; PTHR30461:SF22; SERINE RECOMBINASE PINE-RELATED; 1.
DR Pfam; PF02796; HTH_7; 1.
DR Pfam; PF00239; Resolvase; 1.
DR SMART; SM00857; Resolvase; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF53041; Resolvase-like; 1.
DR PROSITE; PS00397; RECOMBINASES_1; 1.
DR PROSITE; PS00398; RECOMBINASES_2; 1.
DR PROSITE; PS51736; RECOMBINASES_3; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Plasmid {ECO:0000313|EMBL:ACI63056.1}.
FT DOMAIN 2..137
FT /note="Resolvase/invertase-type recombinase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51736"
FT ACT_SITE 10
FT /note="O-(5'-phospho-DNA)-serine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606118-50,
FT ECO:0000256|PROSITE-ProRule:PRU10137"
SQ SEQUENCE 190 AA; 21204 MW; 4A02D4BD38FB12D3 CRC64;
MRLFGYARVS TSQQSLDIQI KGLKEAGVKA SRIFTDKASG SSTDRKGLDL LRMKVEEGDV
ILVKKLDRLG RDTADMIQLI KEFDAQGVAV RFIDDGISTD GEMGKMVVTI LSAVAQAERR
RILERTNEGR QEARLKGIRF GRKRIIDRNS VLALHQQGTG ATDIARRLSI ARSTVYKILE
DESRVNLSKI
//
