ID B6VDH8_9FLAV Unreviewed; 87 AA.
AC B6VDH8;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Nonstructural protein 3 {ECO:0000313|EMBL:ACJ06081.1};
DE Flags: Fragment;
OS dengue virus type 3.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus denguei;
OC Dengue virus.
OX NCBI_TaxID=11069 {ECO:0000313|EMBL:ACJ06081.1};
RN [1] {ECO:0000313|EMBL:ACJ06081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=28D3/06 {ECO:0000313|EMBL:ACJ06081.1};
RA Kukreti H., Chaudhary A., Mittal V., Lal S., Rai A.;
RT "Correlation of NS3 gene sequences of Dengue virus type 3 with clinical
RT disease severity.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of
CC the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.;
CC EC=3.4.21.91; Evidence={ECO:0000256|ARBA:ARBA00024468};
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DR EMBL; FJ375678; ACJ06081.1; -; Genomic_RNA.
DR MEROPS; S07.001; -.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011492; Flavi_DEAD.
DR InterPro; IPR001850; Flavi_NS3_S7.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR Pfam; PF07652; Flavi_DEAD; 1.
DR Pfam; PF00949; Peptidase_S7; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51528; FLAVIVIRUS_NS3PRO; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1..45
FT /note="Peptidase S7"
FT /evidence="ECO:0000259|PROSITE:PS51528"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACJ06081.1"
FT NON_TER 87
FT /evidence="ECO:0000313|EMBL:ACJ06081.1"
SQ SEQUENCE 87 AA; 9494 MW; D037339FF1F4F218 CRC64;
TSGSPIINRE GKVVGLYGNG VVTKNGGYVS GIAQTNAEPD GPTPELEEEM FKKRNLTIMD
LHPGSGKTRK YLPAIVREAI KRRLRTL
//
