ID B6ZK21_9NIDO Unreviewed; 350 AA.
AC B6ZK21;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=sialate O-acetylesterase {ECO:0000256|ARBA:ARBA00013141};
DE EC=3.1.1.53 {ECO:0000256|ARBA:ARBA00013141};
DE Flags: Fragment;
GN Name=HE {ECO:0000313|EMBL:BAG85340.1};
OS Bovine torovirus.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Tornidovirineae; Tobaniviridae; Torovirinae; Torovirus;
OC Renitovirus.
OX NCBI_TaxID=74501 {ECO:0000313|EMBL:BAG85340.1};
RN [1] {ECO:0000313|EMBL:BAG85340.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RBToV-4 {ECO:0000313|EMBL:BAG85340.1};
RA Ito T., Okada N., Okawa M., Fukuyama S., Shimizu M.;
RT "Detection and characterization of bovine torovirus from the respiratory
RT tract in Japanese cattle.";
RL Vet. Microbiol. 136:366-371(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-
CC acetylneuraminate; Xref=Rhea:RHEA:25564, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29006, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:35418; EC=3.1.1.53;
CC Evidence={ECO:0000256|ARBA:ARBA00000954};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-
CC acetylneuraminate; Xref=Rhea:RHEA:22600, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28999, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:35418; EC=3.1.1.53;
CC Evidence={ECO:0000256|ARBA:ARBA00001221};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Host cell membrane {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I
CC membrane protein {ECO:0000256|ARBA:ARBA00004402}.
CC -!- SIMILARITY: Belongs to the influenza type C/coronaviruses
CC hemagglutinin-esterase family. {ECO:0000256|ARBA:ARBA00010920}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB448742; BAG85340.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR GO; GO:0001681; F:sialate O-acetylesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR InterPro; IPR008980; Capsid_hemagglutn.
DR InterPro; IPR007142; Hemagglutn-estrase_core.
DR InterPro; IPR003860; Hemagglutn-estrase_hemagglutn.
DR Pfam; PF03996; Hema_esterase; 1.
DR Pfam; PF02710; Hema_HEFG; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR SUPFAM; SSF49818; Viral protein domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 1..341
FT /note="Haemagglutinin-esterase glycoprotein core"
FT /evidence="ECO:0000259|Pfam:PF03996"
FT DOMAIN 86..225
FT /note="Haemagglutinin-esterase glycoprotein haemagglutinin"
FT /evidence="ECO:0000259|Pfam:PF02710"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAG85340.1"
FT NON_TER 350
FT /evidence="ECO:0000313|EMBL:BAG85340.1"
SQ SEQUENCE 350 AA; 39103 MW; 7616365BF9A02490 CRC64;
SRSDCTNPYS PMSLDIPQQL CSKFSSKSSS SMFLSLHWNT SSSFVSYDYF NCGVEKVFYE
GVNFSPRRQY SCWDEGVDGW IEFKTRFYTK LYQMAATSRC IKLIQLQPPT SLPTLKAAVC
RTGKQLPDNP KFGLLADTNP TSVQFVLPGS SGTTICTKHL VPFCYLNHGC FTTGGSCLPF
GVSYVSDSFY YGYYDATPQI GSIESHDYVC DYLFMEPGTY NASTVGKFFV YPTKSYCMDT
MNITVPVQAV QSIWSEQYAS DDAIGQACKA PYCIFYNKTT SYTVTNGSDA NHGDDEVRMM
MQGLLRNSSC ISPQGSTPLA LYSSQMIYSP NYGSCPQYYK LFETSSDENV
//
