ID B7ANY3_9FIRM Unreviewed; 884 AA.
AC B7ANY3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=BACPEC_00387 {ECO:0000313|EMBL:EEC58640.1};
OS [Bacteroides] pectinophilus ATCC 43243.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=483218 {ECO:0000313|EMBL:EEC58640.1, ECO:0000313|Proteomes:UP000003136};
RN [1] {ECO:0000313|EMBL:EEC58640.1, ECO:0000313|Proteomes:UP000003136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43243 {ECO:0000313|EMBL:EEC58640.1,
RC ECO:0000313|Proteomes:UP000003136};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Bacteroides pectinophilus (ATCC 43243).";
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEC58640.1, ECO:0000313|Proteomes:UP000003136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43243 {ECO:0000313|EMBL:EEC58640.1,
RC ECO:0000313|Proteomes:UP000003136};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; ABVQ01000033; EEC58640.1; -; Genomic_DNA.
DR AlphaFoldDB; B7ANY3; -.
DR STRING; 483218.BACPEC_00387; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_9; -.
DR Proteomes; UP000003136; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 694..710
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 884 AA; 99736 MW; 8DDE88669AC3150E CRC64;
MPQYTPMMQQ YLETKKEYKD CILFYRLGDF YEMFFDDAVT ASRELELTLT GKDCGQEERA
PMCGVPYHAV ESYLNRLISK GYKVAICEQV EDPKTAKGIV KREVIRVVTP GTNLNMQALD
ESKNNYLMSI VYLGDELGVS VVDFSTGDYF VTEVSSGNIL IDEINKFVPS EIIINEYFAM
SGIDLDPVRE KLGISVSALP NWYFDESLCV RKLCEHFHVS RLDGLGLADY STGIVAAGAL
LQYLLETQKN SLEHLTTLMP YTTGKYMLID SSSRRNLELV ETLREKQKRG SLLWVLDKTK
TAMGARRLRA MIEQPLIDHD EIINRQDVIA EFNDNVITRE EIREYLNPVY DLERLMSKIS
CRTANPRDLL AFRSSLQMLP YVKDLIKPFN SVLMQKIYEK LDPLEDIYQL IDSAIVDDPP
IVLREGGIIK EGYNAQADEL RKAKTDGKTW LAGLEEREKE QTGIKNLRVK YNKVFGYYLE
VTNSYKDLVP DNWVRKQTLS NAERYTTEEL KNLEDVILGA EDKLYALEYD LFVDVRDKIA
SQVMRIQSTA KAIAEIDVFA SLALVAEQNN YVRPKINDKG LIDIKDGRHP VVEKMISNDM
FIANDTLLDN NANRISIITG PNMAGKSTYM RQTALIVLMA QVGSFVPASS ANIGIVDRIF
TRVGASDDLA SGQSTFMVEM TEVANILRNA TSKSLLILDE IGRGTSTFDG LSIAWAVVEH
ISNKNLLGAK TLFATHYHEL TELEGTLGGV NNYCIAVKEQ GDDIVFLRKI VKGGADKSYG
IQVAKLAGVP DSVIARAKEL VNDLSDADIS QKAKEIAQYD KKKPDEKYIR KNELEVNQMS
LFDTAKDDDI VDEINSLDIG NMTPIDALNT LYKLQNKIKN RWGR
//
