ID B7FDE2_KLEPN Unreviewed; 286 AA.
AC B7FDE2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
GN Name=blaSHV-108 {ECO:0000313|EMBL:CAP58292.1};
GN Synonyms=blaSHV {ECO:0000313|EMBL:ADR80606.1};
OS Klebsiella pneumoniae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573 {ECO:0000313|EMBL:CAP58292.1};
RN [1] {ECO:0000313|EMBL:CAP58292.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=INSRAKp6896 {ECO:0000313|EMBL:CAP58292.1};
RA Canica M.M.M.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAP58292.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=INSRAKp6896 {ECO:0000313|EMBL:CAP58292.1};
RA Canica M.M., Mendonca N.;
RT "First description of 6 new enzymes SHV in isolates of Klebsiella
RT pneumoniae in Portugal.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAQ03508.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=INSRAKp6896 {ECO:0000313|EMBL:CAQ03508.1};
RA Mendonca N., Ferreira E., Louro D., Canica M., ARSIP Participants;
RT "Molecular epidemiology and antimicrobial susceptibility of extended and
RT broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in
RT Portugal.";
RL Int. J. Antimicrob. Agents 34:29-37(2009).
RN [4] {ECO:0000313|EMBL:ADR80606.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K14C {ECO:0000313|EMBL:ADR80606.1};
RX PubMed=21359845; DOI=10.1007/s00284-011-9899-z;
RA Veras D.L., Alves L.C., Brayner F.A., Guedes D.R., Maciel M.A., Rocha C.R.,
RA de Souza Lopes A.C.;
RT "Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates
RT obtained from hospital and community infections and from the microbiota of
RT healthy individuals in Recife, Brazil.";
RL Curr. Microbiol. 62:1610-1616(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526,
CC ECO:0000256|RuleBase:RU361140};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009, ECO:0000256|RuleBase:RU361140}.
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DR EMBL; HM751100; ADR80606.1; -; Genomic_DNA.
DR EMBL; AM922309; CAP58292.1; -; Genomic_DNA.
DR EMBL; AM941849; CAQ03508.1; -; Genomic_DNA.
DR RefSeq; WP_063864611.1; NZ_WULJ01000015.1.
DR AlphaFoldDB; B7FDE2; -.
DR SMR; B7FDE2; -.
DR MEROPS; S11.A01; -.
DR KEGG; ag:CAQ03508; -.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR023650; Beta-lactam_class-A_AS.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR PRINTS; PR00118; BLACTAMASEA.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS00146; BETA_LACTAMASE_A; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|RuleBase:RU361140};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..286
FT /note="Beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015087400"
FT DOMAIN 45..258
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 286 AA; 31251 MW; 5C72427176AD8583 CRC64;
MRYIRLCIIS LLATLPLAVH ASPQPLEQIK QSESQLSGRV GMIEMDLASG RTLTAWRADE
RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD YSPVSEKHLA DGMTVGELCA
AAITMSDNSA ANLLLAIVGG PAGLTAFLRQ IGDNVTRLDR WETELNEALP GDARDTTTPA
SMAATLRKLL TSQRLSARSQ RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGAGERGARG
IVALLGPNNK AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR
//