ID B7G0V6_PHATC Unreviewed; 1987 AA.
AC B7G0V6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Phosphodiesterase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHATRDRAFT_36270 {ECO:0000313|EMBL:EEC47585.1};
OS Phaeodactylum tricornutum (strain CCAP 1055/1).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Naviculales; Phaeodactylaceae;
OC Phaeodactylum.
OX NCBI_TaxID=556484 {ECO:0000313|EMBL:EEC47585.1, ECO:0000313|Proteomes:UP000000759};
RN [1] {ECO:0000313|EMBL:EEC47585.1, ECO:0000313|Proteomes:UP000000759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCAP 1055/1 {ECO:0000313|EMBL:EEC47585.1,
RC ECO:0000313|Proteomes:UP000000759};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [2] {ECO:0000313|Proteomes:UP000000759}
RP GENOME REANNOTATION.
RC STRAIN=CCAP 1055/1 {ECO:0000313|Proteomes:UP000000759};
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA Lindquist E., Shapiro H., Lucas S., Glavina del Rio T., Pitluck S.,
RA Rokhsar D., Bowler C.;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM000613; EEC47585.1; -; Genomic_DNA.
DR RefSeq; XP_002180933.1; XM_002180897.1.
DR STRING; 556484.B7G0V6; -.
DR PaxDb; 2850-Phatr36270; -.
DR GeneID; 7201609; -.
DR KEGG; pti:PHATRDRAFT_36270; -.
DR eggNOG; KOG3689; Eukaryota.
DR eggNOG; KOG4171; Eukaryota.
DR InParanoid; B7G0V6; -.
DR OrthoDB; 52698at2759; -.
DR Proteomes; UP000000759; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR002073; PDEase_catalytic_dom.
DR InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00233; PDEase_I; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF82199; SET domain; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51845; PDEASE_I_2; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000759};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 557..691
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 776..1012
FT /note="PDEase"
FT /evidence="ECO:0000259|PROSITE:PS51845"
FT DOMAIN 1387..1789
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 22..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1987 AA; 223900 MW; DA2764FF66483A8D CRC64;
MVTLESLQEN AAAEMDDSCS MSAYSVSDND DGHVDSSEGS SSAAKHSRAS ENIETTIAKT
ETRAVARTRI FVAFILVVSM IAVAVLIYIF TSKGEQDKFE QKFEDDSTQI LETIGSTLDV
TLSSTDAFIA NIMAYARYSN STWPFVTKPE YAVEAAKLLV LSKAVYIGEY VFVAEEEKLA
WQNYSVHHDS WVQEGIDLQR RNPDYKGIII DEFQTLGLIH DNFAQERIGG PYMPTWQVAP
VVPIYFPYNW DASTHERMGP TIKHIFEKQH VVIGAASGVA DPNNPDQILQ AEYDALWIKN
YISEDDNPSE PFSEIYYPMI DAPGQVRIDV DQPQDIVGFS VITFFWRDLI RDILYEDSKG
VVVVIENSCN QVWTYQIDGP NTTYLGPGDL HDSNFDGMRR SAPLYNLREL FSNSGVYTGI
PLGEDYCVHT LHVYPSTEMR NEFITHGPII YTVSAVAFFV LTLLAFLIYD WKVERRQKKV
MATAVQTSKI VSSLFPSNVR DRLFQGRETG EHGLPFVGLE PQKRRLKSFL SSGSDKSAEA
REVDVDRPIA DLFPNCTVMF ADISGFTAWS SVREPAQVFR LLETLYGAFD EIANKRRVFK
VETIGDSYVA VTGLPEPRKD HAVVMARYAF DCRSKMAELT KQLETTLGPD TGDLQFRFGL
NSGPVTAGVL RGEKTRFQLF GDTVNTAARM ESSGARSKIQ CSQTTADSLV EAGKEHWLKA
RSELVEAKGK GRMQTFWIEP REHQASHVSS APSAEVAALF DEKTQRLVDW NTDVLARLIR
QVVARRNVSI KGKKKSFKPS VSKIEFQCDL SKSNGTALDE VREIIELPEF DHSLASKQED
PDSINLGQDI LGELREYIVN IASMYHNNPF HNFEHASHVT MSVVKLLSRI VAPDEVYSDA
GVKDSHKLAS SLHDHTYGIT SDPLTQFACV FSALIHDVDH SGVPNAQLVK ERTHIASFYK
GKSVAEQNSV DIAWDLLMSD SFQKLRTKIA SNPDELRRFR QLVVNSVMAT DIMDKDLGAA
RKARWNKAFA QGSERAKEDT VATNSRDDIN RKATIVIEHL IQASDVSHTM QHWHIYRKWN
ERFFIECYQA YTSGRAEANP VDNWYKGEMG FFDFYIIPLA KKLSECGVFG VSSDEYLNYA
VRNRQEWEER GQEVVASMIE KVERREASQE VDCEGRREKA PLHNRGDDMT RMMHHLTRSS
GNSFFLGQFG ISILVIGTAA SQKAVTENPF FFQAVGRGPV RPRLSVDFHH FHADNFLACR
KRCNPSAAPA APVAPALAAG SCYIRLIRLL GDRIVCRTRK HRREMRRPRP SEEAKGTFLS
TPQHTRTGDS WKNGSYWGAA LSQRKAVLVV CLLVAAGLTR RNNLPLIPAT VSTSGTVRSA
ADTKNKCTVW LAPSSLKGYS GYGIFTTRDI PKGGAVLGGP DGLSIPIQDY LDTKQANKDA
KKAWIDVWDN YWWGRGVPDH VNYFAGTDVV DYQIAFGALP NHHCLLDSLH SQYPKPPFMD
GLVDRFKDPS AGAFTYSRGR EFLVNRDIKS GEELFLSYGY CRHDDEDIPD WTSRIFMEED
FSAAVDMIQN GLDFDIQGAL IVPTSSAPLA AELLPKSRKE LDEMLAKAKS KKERIHYLAT
HQGLNMRTPE WIRANGMCME NMIPKQSTIS AIGQGGFAQF PIRKGELVTP APLLQILDRS
ALDLYDSSGK KSGTQLLLNY CFGHCKSTLL LCPDTNAVLI NHCSSRSNVC SSQGPNADYR
WSTGWDPTSD DWRKKSLQEL ALETGRGLAL EIFATRDILP GEEVFIDYGP EFELAWNQHV
RIWKPPPPPQ GPWITAQAAN DSEGPIFDFL VTGNLRRTTQ HPYLFTGCQY WPTSEDNVEA
YRESNRAWTA MTDRALMTHY ANSGSRYIYW DEEGYTNHAD TSHWPCSVLR QEPNGKYVVR
IHQNPWEDSL PWHQNSLPRL LHSYSRESIH YFVKPFSNDQ QMPGAFRHSM MIRDGMFPAQ
WMNRKAD
//
