ID B7GDQ8_PHATC Unreviewed; 998 AA.
AC B7GDQ8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Antiviral helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHATRDRAFT_50326 {ECO:0000313|EMBL:EEC43389.1};
OS Phaeodactylum tricornutum (strain CCAP 1055/1).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Naviculales; Phaeodactylaceae;
OC Phaeodactylum.
OX NCBI_TaxID=556484 {ECO:0000313|EMBL:EEC43389.1, ECO:0000313|Proteomes:UP000000759};
RN [1] {ECO:0000313|EMBL:EEC43389.1, ECO:0000313|Proteomes:UP000000759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCAP 1055/1 {ECO:0000313|EMBL:EEC43389.1,
RC ECO:0000313|Proteomes:UP000000759};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [2] {ECO:0000313|Proteomes:UP000000759}
RP GENOME REANNOTATION.
RC STRAIN=CCAP 1055/1 {ECO:0000313|Proteomes:UP000000759};
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA Lindquist E., Shapiro H., Lucas S., Glavina del Rio T., Pitluck S.,
RA Rokhsar D., Bowler C.;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM000630; EEC43389.1; -; Genomic_DNA.
DR RefSeq; XP_002185257.1; XM_002185221.1.
DR AlphaFoldDB; B7GDQ8; -.
DR STRING; 556484.B7GDQ8; -.
DR PaxDb; 2850-Phatr50326; -.
DR GeneID; 7198985; -.
DR KEGG; pti:PHATRDRAFT_50326; -.
DR eggNOG; KOG0948; Eukaryota.
DR InParanoid; B7GDQ8; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000000759; Chromosome 28.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000759}.
FT DOMAIN 96..252
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 322..526
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 112093 MW; 88A68BB191BAE29E CRC64;
MADLNDLFGA FDGNDSDHGS SSLQDEPAVL PKKPRLEERN SQRSSSPPED ELSNIRSYSA
FPKNLPAGFA PPRVEPPQEP AKTYAFKLDP FQAQAVAYID KEESVLVAAH TSAGKTAVAE
YAVAKSLKAG QRVIYTSPIK ALSNQKFRDL QEEFDDVGLM TGDITINPDA TCLVMTTEIL
RSMLYRGSEL MREISWVIYD EVHYMRDAER GVVWEESIIL LPHRVRFVFL SATIPNATQF
ADWIAEIHHQ PCHVVYTNYR PTPLQHYIFP QGGEGLHLVV DERGKFREAN FQKAMASLQS
GNGNAKKRGR GKQGGGAGQF ADLHRIVKLI MERNLNPCII FSFSKKDCEK YALALNQEDY
TDDVEKDLVA QVYHNAIDSL SDDDRKLPQV EALLPLLKRG IGIHHGGLLP ILKEIVEILF
TEGLIKALFA TETFSIGINA PAKTVVFTNT RKWDGKDFRW VSSGEYIQMS GRAGRRGKDD
RGIVIQMVDE KMEPAVCKDM LYGAPNPLNS SYRISYNMLL NLMRVEDVDP EYLIRASFHQ
FQREKDAPGL IADAEILESQ AETVDFQSEE EVTLVAEYYQ MDQQLLLTRR KIGTIVRKPG
YVLKFLQAPG RFLDVILDGE EFGWGVLVSC KKRQGIGSGG EAGRIASLTN QPEYILDVLL
NCVDRHFDKN RKGKDEDAEN VNLLIERLSA VRIFIPQDIT TPEARRKVST SVKEVSKRFP
DGIPLLDPVA DLGINDDAFM TLLKRAETLT NLLAEHKLAN DFVDSSRLEL VQRYEKKADM
LERAKTLREE ARNCQTMAMK DDLKKMKRVL KKLGHVDAGG VIQTKGRTAC EINTSDELVV
VELIFGGIFN DLSVEQSVAL LSCMTFDERN KNEDDPASGL KSFLSNPFYK LQEVARTVAR
VVISCGIDLN EDEFVDKFNP GMMEAVFAWC KGAKFIEVQK LTGSFEGTTI RTLRRLEELV
RQITAAAKAI GNHELEAKFE KGSELIKRDI VFCSSLYL
//
