ID B7GKY1_ANOFW Unreviewed; 744 AA.
AC B7GKY1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Subtilisin-type proteinase with two SLH domains {ECO:0000313|EMBL:ACJ34959.1};
GN OrderedLocusNames=Aflv_2606 {ECO:0000313|EMBL:ACJ34959.1};
OS Anoxybacillus flavithermus (strain DSM 21510 / WK1).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Anoxybacillus.
OX NCBI_TaxID=491915 {ECO:0000313|EMBL:ACJ34959.1, ECO:0000313|Proteomes:UP000000742};
RN [1] {ECO:0000313|EMBL:ACJ34959.1, ECO:0000313|Proteomes:UP000000742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21510 / WK1 {ECO:0000313|Proteomes:UP000000742};
RX PubMed=19014707; DOI=10.1186/gb-2008-9-11-r161;
RA Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A.,
RA Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V.,
RA Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.;
RT "Encapsulated in silica: genome, proteome and physiology of the
RT thermophilic bacterium Anoxybacillus flavithermus WK1.";
RL Genome Biol. 9:R161.1-R161.16(2008).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; CP000922; ACJ34959.1; -; Genomic_DNA.
DR AlphaFoldDB; B7GKY1; -.
DR STRING; 491915.Aflv_2606; -.
DR KEGG; afl:Aflv_2606; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_373269_0_0_9; -.
DR Proteomes; UP000000742; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR001119; SLH_dom.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF00395; SLH; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51272; SLH; 2.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000000742};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..744
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002855989"
FT DOMAIN 561..624
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT DOMAIN 682..743
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT ACT_SITE 222
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 256
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 412
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 744 AA; 82623 MW; AF6682ADE31E7A7B CRC64;
MASVSRWLWL CVVCFLFPSV VQADEKEEWI VQVQHPSNFS DIQSYVVDTV GTFAKVVVTE
EEREHISRLP FVLKMEKNDM KRAAVNDPLF SEQWSLGMVR WHFPTVTSVN RLIGKTMIVD
GREEVYDGEA FFGEHIVIAL GEETLSRLSV TVDHIEGPWR IQVKDEKGAT LGENEGELPR
LDVLIPRPSS TIHLYVTAPN WTNRPRIVEL KGVNHVLVAV VDSGVVQHED LNDHVLYSVS
VDYAENKRYA DDTFGHGTHV TGILAASVNN GKGIAGLIGD APVDILPIKV LDRYGVGGDF
EIAKGVKYAL EQGASIINLS LAGQGETEVL KAVIEEAVKR GVHVVAAAGN SHMPTTNIYP
ASYPGVITVA AVDRQQMPLS ISNYGWDVEV SAPGDFLIST YPSGYRAMRG TSMAAPHVSA
LLAVLRAMYP EEDAFQLRSR IWKTAKDVYW RGYDMYTGYG IIQWQQALAL SAPSNIDWLN
LQPGQPIEKN RTYMLGLSSR FVGKNGHLFI NGKLVHSFVI HQEMMPFRLF DLAKQQGDVA
VVITDEQQRV IASDVRAVPI RPTPFSDVKK TYWAYSDILQ AQQFGMIRGY GDGTFRPNTP
LTRGESMVML ARLFGWEVPS LLSAPFVDVP LTATNALLVA TAAEKGIVKG TEGKALLHEQ
LTRGQFALLL MRALQLENEP IRSVSPFQDV TQQDMWKAVQ LLAERGIVAK TSYFHPNEPV
TRAQMCAMLV RVSTLIRQYS TKTA
//
