ID B7HRI2_BACC7 Unreviewed; 596 AA.
AC B7HRI2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Sodium/hydrogen exchanger family protein {ECO:0000313|EMBL:ACJ78695.1};
GN OrderedLocusNames=BCAH187_A4667 {ECO:0000313|EMBL:ACJ78695.1};
OS Bacillus cereus (strain AH187).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=405534 {ECO:0000313|EMBL:ACJ78695.1, ECO:0000313|Proteomes:UP000002214};
RN [1] {ECO:0000313|EMBL:ACJ78695.1, ECO:0000313|Proteomes:UP000002214}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AH187 {ECO:0000313|EMBL:ACJ78695.1,
RC ECO:0000313|Proteomes:UP000002214};
RA Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B.,
RA Okstad O.A., Ravel J., Sutton G.;
RT "Genome sequence of Bacillus cereus AH187.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001177; ACJ78695.1; -; Genomic_DNA.
DR AlphaFoldDB; B7HRI2; -.
DR KEGG; bcr:BCAH187_A4667; -.
DR HOGENOM; CLU_005912_10_1_9; -.
DR Proteomes; UP000002214; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..393
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 405..486
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02254"
SQ SEQUENCE 596 AA; 65973 MW; 4B00EC0BEE811293 CRC64;
MVESLLLSIV IIITLGIASQ WTAWRFQLPA IVVMAVAGLL IGPVFGIINP KEVLGDVFSP
LVSLSVAIIL FEGSLSLDIR ELRGLSKPVF RIVTFGAFIA WIAGSLAAHY VAGLDWAVAF
IIGGLFIVTG PTVIIPLLRQ ARLKPRTAAI LKWEGIIVDP FGALLAVFAF QIVNFLTKEN
VQLHTLLYFF AGSLFAMVLG YVFSIFMSYM ILKGKVPEYL KAPILLVTVL LCFGIADEVM
HETGMLAVTV MGITLARMKK YISSIGDIRH FNENISVLLT STVFIILTAS LPRTTIMEIF
SWPIISFVLM MLFVVRPLSI WISTIGTELT KAERALVGWI APRGIVALTV SSYFATELLQ
EGYKDASILT ALTFALVITT VCAHGFSIGF LAKRLGLANT EPPGILISGA STFSSAFALH
CKEMGIPSLI VDVSEEHLQC AKVKGLNTYN GQVLSEQLQF EVDMNQYEYL IAVTDTDSYN
VLVANTYVPQ FGHHNTFLLP IHDVEKIEQE RISLSKKAHL LFGQNEIYEE LNRKIEDGYT
FKTIQVVEEQ KINKEEIDSE DLILFIRHRD GSLTFSTLYK YIAVMPGDEL VVLAKQ
//
