ID B7IFT2_THEAB Unreviewed; 773 AA.
AC B7IFT2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Membrane protein, putative {ECO:0000313|EMBL:ACJ74946.1};
GN OrderedLocusNames=THA_455 {ECO:0000313|EMBL:ACJ74946.1};
OS Thermosipho africanus (strain TCF52B).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Thermosipho.
OX NCBI_TaxID=484019 {ECO:0000313|EMBL:ACJ74946.1, ECO:0000313|Proteomes:UP000002453};
RN [1] {ECO:0000313|EMBL:ACJ74946.1, ECO:0000313|Proteomes:UP000002453}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TCF52B {ECO:0000313|EMBL:ACJ74946.1,
RC ECO:0000313|Proteomes:UP000002453};
RX PubMed=19124572; DOI=10.1128/JB.01448-08;
RA Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D.,
RA Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.;
RT "The genome of Thermosipho africanus TCF52B: lateral genetic connections to
RT the Firmicutes and Archaea.";
RL J. Bacteriol. 191:1974-1978(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001185; ACJ74946.1; -; Genomic_DNA.
DR RefSeq; WP_012579594.1; NC_011653.1.
DR AlphaFoldDB; B7IFT2; -.
DR STRING; 484019.THA_455; -.
DR KEGG; taf:THA_455; -.
DR eggNOG; COG1033; Bacteria.
DR HOGENOM; CLU_352267_0_0_0; -.
DR OrthoDB; 49344at2; -.
DR Proteomes; UP000002453; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..391
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 773 AA; 87408 MW; 2BD96CECDA13D213 CRC64;
MIERFAKFLL KKSSLFILIL SLIGLLFGIY SLLNLKVNAE LTELAPEKIP EFKDMVKFTN
EKVVSNTLLL VIELENKKIN VNEFVEKLKD AFEETPYISK AEAFDDPETM LKYGIFTIDE
NSLTNVLNYY NAVINVEPRS AIDFRFWRNL GIAISTVSEY ANSFLSRSGI KKYYLISNDG
NVILMNFSMS KPVTDIDFLN KAIPDLKNIA SKLSKEFEAN ILFSGSAMNN YIGNKQVTKD
FQITTIVSLV GISLLLLISY GSSKTMLFMF YSMILAMGTS LGIIVLLFKQ INIITSFVNA
MLLGLGIDYG IHITAKIHEN LRIYGKTNES IVEAFKENFT PSFVSAITTS IALLALALSP
SKPLQEMGIS SGIGVMIFFI YMNFLVPAFY SRFKQSINIP KKEYFSSFLE LLRRIKPIKA
FVWFVVIIFS AFSYLAVKNF SYTPPGLVPE SSEAVKALEI AEEKFGEFGV GQIVIAAKSI
DELKEIKNEI ENSKYFSNTF SLLSFVEEPE KLEEIRPSFY ETVYKVINEP ILDVVFKKYG
LYNSLLETLS LLRTAKTYDD VISSIEKDIP ALFFYDTNNT RYYLLYAKEK VSLWRDNNLK
KIFDEELKGK KVFGYPALFY KVMVYLVNST SKAVYFVFLA IIITLLIDLR SFLKSLKVTF
YVVLSILATI GIGYVALKID LTFLNLLIIP IFLGIGVDSM VHLSHSILHG RDSIMKTEKA
VTISVLTTII AFGSFILAQG ELLKEFGELV SIGLLVSWFV SIFIYLSSID KKG
//
