ID UBIE_BACC2 Reviewed; 237 AA.
AC B7IP91;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 01-MAY-2013, entry version 33.
DE RecName: Full=Demethylmenaquinone methyltransferase;
DE EC=2.1.1.163;
DE AltName: Full=Menaquinone biosynthesis methyltransferase ubiE;
GN Name=ubiE; OrderedLocusNames=BCG9842_B3776;
OS Bacillus cereus (strain G9842).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=405531;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G9842;
RA Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA Ravel J., Sutton G.;
RT "Genome sequence of Bacillus cereus G9842.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
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DR EMBL; CP001186; ACK95618.1; -; Genomic_DNA.
DR RefSeq; YP_002444953.1; NC_011772.1.
DR ProteinModelPortal; B7IP91; -.
DR STRING; 405531.BCG9842_B3776; -.
DR EnsemblBacteria; ACK95618; ACK95618; BCG9842_B3776.
DR GeneID; 7183635; -.
DR KEGG; bcg:BCG9842_B3776; -.
DR PATRIC; 18898511; VBIBacCer50903_1411.
DR eggNOG; COG2226; -.
DR HOGENOM; HOG000249463; -.
DR KO; K03183; -.
DR OMA; DGHEETH; -.
DR ProtClustDB; PRK00216; -.
DR BioCyc; BCER405531:GI5L-3026-MONOMER; -.
DR UniPathway; UPA00079; UER00169.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR014122; MenG_heptapren.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR02752; MenG_heptapren; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Transferase.
FT CHAIN 1 237 Demethylmenaquinone methyltransferase.
FT /FTId=PRO_1000187728.
SQ SEQUENCE 237 AA; 26901 MW; 4DFD607F7E9FE5CB CRC64;
MQQSKEERVH DVFEKISDKY DVMNSVISFQ RHKAWRKETM RIMDVQPGSQ ALDVCCGTAD
WTIALAGAVG EQGKVVGLDF SENMLSVGKQ KVEALQLKQV ELLHGNAMEL PFEDNTFDYV
TIGFGLRNVP DYMHVLKEMT RVVKPGGKVI CLETSQPTMI GFRQGYILYF KYIMPLFGKM
FAKSYKEYSW LQESASTFPG MKELAQMFEQ AGLERVQVKP FTFGVAAMHL GIKPESK
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