ID   B7J6E0_ACIF2            Unreviewed;      1054 AA.
AC   B7J6E0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=ATP-dependent helicase, DEAD/DEAH box family {ECO:0000313|EMBL:ACK78916.1};
GN   OrderedLocusNames=AFE_2375 {ECO:0000313|EMBL:ACK78916.1};
OS   Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768
OS   / NCIMB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)).
OC   Bacteria; Pseudomonadota; Acidithiobacillia; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=243159 {ECO:0000313|EMBL:ACK78916.1, ECO:0000313|Proteomes:UP000001362};
RN   [1] {ECO:0000313|EMBL:ACK78916.1, ECO:0000313|Proteomes:UP000001362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455
RC   {ECO:0000313|Proteomes:UP000001362};
RX   PubMed=19077236; DOI=10.1186/1471-2164-9-597;
RA   Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R.II.,
RA   Eisen J.A., Holmes D.S.;
RT   "Acidithiobacillus ferrooxidans metabolism: from genome sequence to
RT   industrial applications.";
RL   BMC Genomics 9:597-597(2008).
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DR   EMBL; CP001219; ACK78916.1; -; Genomic_DNA.
DR   RefSeq; WP_012537158.1; NC_011761.1.
DR   AlphaFoldDB; B7J6E0; -.
DR   STRING; 243159.AFE_2375; -.
DR   PaxDb; 243159-AFE_2375; -.
DR   GeneID; 66433352; -.
DR   KEGG; afr:AFE_2375; -.
DR   eggNOG; COG1204; Bacteria.
DR   HOGENOM; CLU_010962_0_0_6; -.
DR   Proteomes; UP000001362; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd17921; DEXHc_Ski2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR   PANTHER; PTHR47961:SF6; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ACK78916.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001362}.
FT   DOMAIN          310..492
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          583..744
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1054 AA;  117280 MW;  771D44FCB12A4976 CRC64;
     MNHWLLDAMA ERRSHALREA DRVQFHQEMG REVPAFDEAL LRETAAALEI AVLDLKVDRL
     ADEPEQLALS RQAAADAFRL LRMLPLPADP MVAGSHLLRA SVLAVLGDRG ADAARWLRTL
     DEAGHWPALP LEARNWGKRC RAALTDVWLR LVRKRGWSDR DAVLERVAAL RSAQEEFERD
     YLHTFAPLEA KRTALELIGI YHLAKAADVL AHYITDGVVD GSFQVQPLLD SHFDRAIDAC
     DAAQLVELGP MTRLLARASA QMVDNALWTV TRKVNSRVTD FVRELVKRGR GDRALFDVLP
     PQRRTLAERG LLGSSRQAVV VSLPTSSGKT LIAQFRMLQA LNQFEDRKGW VAYLAPSRAL
     VNQVTRQLRR DFQPLGLMVE RISPAMEIDG IEAGVLAEAN DEVRFRILVA TPEKFDLMLR
     QGWEEKIGRP LTLVVVDEAH TIQDKVRGLR LELLLATINR ECRDAQFLLL TPFIQNAREV
     ARWLGGQNSE DISLGVDWQP NDRAIGIVSP VDDGRKNGRS RDYRLDFETV HTTRPSIVLD
     EAFSLGKDET LAGTLSEARD VGALAGITAR KLMVRGPVIA MHSRPDYVWK LAERLKSGQA
     GAMSDDVRFV QEYVAAELGA QYPLVDLLAH RIGMHHGGLP EEIRMLMEWL FEKGQLDVLA
     ATTTIAQGVN FPVSGVVMAA TQYPYGQTMP PEDFWNIAGR AGRVSQGQLG VVALVAKDES
     EVAQRREFIN SNTGDLNSAL IQLAQAASGE LSDLGRIVYS RPEWSSFLQY LVHTYRQMGA
     PSNFADQIEQ VLRGTLGFEK LRTADSQLAR HLLDGIRTYV DDMVRPQQPL KLVDSTGFSL
     QSIKTVLTHK GDIGPDSWNR ERLFREGDRT LQDMMGVLLR VPELRENLET VLGGRAPDGD
     KLALILKDWV NGEEITTIAA RHFRKEGYDE VTALTKCGQN LFGKLAQTSS WGLNALLAIT
     ASNLSDDEHT RLANLPSQVF YGVATDEAIA LRLLGVPRKA ATPLAKVLKL DATTSLPTIR
     QRLSALTERD WLQALGPVGG TYRKAWQIMD GTLD
//