ID B7JNH4_BACC0 Unreviewed; 296 AA.
AC B7JNH4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Putative 2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:ACK87423.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:ACK87423.1};
GN OrderedLocusNames=BCAH820_2372 {ECO:0000313|EMBL:ACK87423.1};
OS Bacillus cereus (strain AH820).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=405535 {ECO:0000313|EMBL:ACK87423.1, ECO:0000313|Proteomes:UP000001363};
RN [1] {ECO:0000313|EMBL:ACK87423.1, ECO:0000313|Proteomes:UP000001363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AH820 {ECO:0000313|EMBL:ACK87423.1,
RC ECO:0000313|Proteomes:UP000001363};
RA Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA Ravel J., Sutton G.;
RT "Genome sequence of Bacillus cereus AH820.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001283; ACK87423.1; -; Genomic_DNA.
DR RefSeq; WP_000719419.1; NC_011773.1.
DR AlphaFoldDB; B7JNH4; -.
DR KEGG; bcu:BCAH820_2372; -.
DR HOGENOM; CLU_035117_1_1_9; -.
DR Proteomes; UP000001363; Chromosome.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ACK87423.1}.
FT DOMAIN 3..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 167..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 296 AA; 32321 MW; 3DE977C294AF973E CRC64;
MKKIGFIGLG NMGLPMSKNL VKSNYTVYGV DLNKDAEVSF EKEGGIIGLS ISKLAETCDV
IFTSLPSPRA VEAVYFGQEG LFENSHSNVV LIDTSTVSPQ LNKQLEEAAK EKKVDFLAAP
VSGGVIGAEN RTLTFMVGGS KEVYEKTESI MGVLGANIFH VSEQIDSGTT VKLINNLLIG
FYTAGVSEAL TLAKKSNMDL DKMFDILNVS YGQSRIYERN YKSFIASENY EPGFTVNLLK
KDLGFAVDLA KESELHLPVS EMLLNVYEEA SEAGYGENDM AALYKKVSEQ LISNQK
//
