ID B7KRA3_METC4 Unreviewed; 954 AA.
AC B7KRA3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ACK83839.1};
GN OrderedLocusNames=Mchl_3001 {ECO:0000313|EMBL:ACK83839.1};
OS Methylorubrum extorquens (strain CM4 / NCIMB 13688) (Methylobacterium
OS extorquens).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylorubrum.
OX NCBI_TaxID=440085 {ECO:0000313|EMBL:ACK83839.1, ECO:0000313|Proteomes:UP000002385};
RN [1] {ECO:0000313|Proteomes:UP000002385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Marx C., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium chloromethanicum
RT CM4.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACK83839.1, ECO:0000313|Proteomes:UP000002385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM4 / NCIMB 13688 {ECO:0000313|Proteomes:UP000002385};
RX PubMed=22887658; DOI=10.1128/JB.01009-12;
RA Marx C.J., Bringel F., Chistoserdova L., Moulin L., Farhan Ul Haque M.,
RA Fleischman D.E., Gruffaz C., Jourand P., Knief C., Lee M.C., Muller E.E.,
RA Nadalig T., Peyraud R., Roselli S., Russ L., Goodwin L.A., Ivanova N.,
RA Kyrpides N., Lajus A., Land M.L., Medigue C., Mikhailova N., Nolan M.,
RA Woyke T., Stolyar S., Vorholt J.A., Vuilleumier S.;
RT "Complete genome sequences of six strains of the genus Methylobacterium.";
RL J. Bacteriol. 194:4746-4748(2012).
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DR EMBL; CP001298; ACK83839.1; -; Genomic_DNA.
DR RefSeq; WP_015951243.1; NC_011757.1.
DR AlphaFoldDB; B7KRA3; -.
DR KEGG; mch:Mchl_3001; -.
DR HOGENOM; CLU_000445_70_20_5; -.
DR Proteomes; UP000002385; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR024478; HlyB_4HB_MCP.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF12729; 4HB_MCP_1; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF12860; PAS_7; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..276
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 285..326
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 554..691
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 700..950
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 954 AA; 102381 MW; 1BFAE408191F2EBF CRC64;
MSLPRRPFGF SLGRTAVGAV LRGGRTIRGR IFLAFLMLSA ITAALGGYAA FGIMTTGALV
DKTYDRSLMA INYARAAATD LAMLQAAVAR ARLAGDSAER RTLEARIEAL TQSFEEDLEI
AADRAQSERA TREAAAAKDA VAHWLAARSE FGPDQQTADV WQALDAHAAV AEQHIDLLIN
FTAGDGFSYR QTARADVARD VRLSIFATSL AIVLSGIVAL LLLRQIVRPV ADASTVASRI
AAGELTVRVP EGGDDEFGAL LRAMAVMRDN IAAMMQEEVA QRRSAQSLLA DAVQGSIEGI
VVVDAGGRIV LANARAAALL GIDQAEPGHR PLSDTRGSAV ADALLAMPGH ATLTAETHTA
DGRWLRISRS PTREGGFVAV CSDVSLLKEQ EDQLKRSNAQ LDAALSNMLQ GLCLYDAEGG
LLVYNRRFCD MFGVDAAALR PGMSIRDVAR LVEASSDSGR AIDLLVEQEA LLQRGLSASL
CCPIRTDCIV ALKQQPTAEG GWIATYEDVT QRYEAEARII TMARKDALTG LANRMVFGER
LEEAAARLDE GAGAGFATLC LDLDRFKEVN DTLGHPIGDG LLRSVAERLQ GCLRDTDLVA
RLGGDEFAIV QAGVQAGTHA RRDASALAKR LIAAFQQPFL LDGHTVTVGL SIGISLAPEH
GTSPEKLLKS ADLALYRAKA TGRGCWAFFD EEMDVELRKR RALESDLKKA VGNGEFELVF
QPIVKLDRQR IASCEALLRW RHPERGYVSP ADFIPLAEET GTIGEIGEWV LRKACSEAAT
WPSNIRVAVN VSAAQFKNAA VVRAVMDALA ASGLPAHRLE LEITESVLLN DSVTTLATLH
TLKRLGVRVA MDDFGTGFSS LSYLQSFPFD KIKIDQSFVR NLAAPGNSRL IVRSVVGLGR
SLGITTTAEG IETEAQLEQL RLEGCDEGQG YLFSRPVPSA TIRELVTALG RNAA
//
