ID B7L9G5_ECO55 Unreviewed; 324 AA.
AC B7L9G5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=2-keto-3-deoxygluconate permease {ECO:0000256|HAMAP-Rule:MF_00070};
DE Short=KDG permease {ECO:0000256|HAMAP-Rule:MF_00070};
GN Name=kdgT {ECO:0000256|HAMAP-Rule:MF_00070,
GN ECO:0000313|EMBL:CAV01098.1};
GN OrderedLocusNames=EC55989_4388 {ECO:0000313|EMBL:CAV01098.1};
OS Escherichia coli (strain 55989 / EAEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585055 {ECO:0000313|EMBL:CAV01098.1, ECO:0000313|Proteomes:UP000000746};
RN [1] {ECO:0000313|Proteomes:UP000000746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=55989 / EAEC {ECO:0000313|Proteomes:UP000000746};
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Catalyzes the proton-dependent uptake of 2-keto-3-
CC deoxygluconate (KDG) into the cell. {ECO:0000256|HAMAP-Rule:MF_00070}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-
CC deoxy-D-gluconate(out) + H(+)(out); Xref=Rhea:RHEA:29943,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57990; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00070};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_00070}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_00070}.
CC -!- SIMILARITY: Belongs to the KdgT transporter family.
CC {ECO:0000256|ARBA:ARBA00006430, ECO:0000256|HAMAP-Rule:MF_00070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00070}.
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DR EMBL; CU928145; CAV01098.1; -; Genomic_DNA.
DR AlphaFoldDB; B7L9G5; -.
DR KEGG; eck:EC55989_4388; -.
DR HOGENOM; CLU_057476_0_1_6; -.
DR Proteomes; UP000000746; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015649; F:2-keto-3-deoxygluconate:proton symporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00070; KdgT; 1.
DR InterPro; IPR004684; 2keto-3dGluconate_permease.
DR InterPro; IPR018395; 2keto-3dGluconate_permease_sub.
DR NCBIfam; TIGR00793; kdgT; 1.
DR Pfam; PF03812; KdgT; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00070};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00070};
KW Reference proteome {ECO:0000313|Proteomes:UP000000746};
KW Sugar transport {ECO:0000256|HAMAP-Rule:MF_00070};
KW Symport {ECO:0000256|HAMAP-Rule:MF_00070};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_00070}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 117..141
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 153..178
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 184..201
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
SQ SEQUENCE 324 AA; 33552 MW; 198F321841337461 CRC64;
MTHQPLKICR QVMEMQIKRS IEKIPGGMML VPLFLGALCH TFSPGAGKYF GSFTNGMITG
TVPILAVWFF CMGASIKLSA TGTVLRKSGT LVVTKIAVAW VVAAIASRII PEHGVEVGFF
AGLSTLALVA AMDMTNGGLY ASIMQQYGTK EEAGAFVLMS LESGPLMTMI ILGTAGIASF
EPHVFVGAVL PFLVGFALGN LDPELREFFS KAVQTLIPFF AFALGNTIDL TVIAQTGLLG
ILLGVAVIIV TGIPLIIADK LIGGGDGTAG IAASSSAGAA VATPVLIAEM VPAFKPMAPA
ATSLVATGHC DFDSGANSYL YLVT
//
