ID B7LV31_ESCF3 Unreviewed; 1105 AA.
AC B7LV31;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Diguanylate cyclase, GGDEF domain signalling protein {ECO:0000313|EMBL:CAQ89656.1};
GN Name=yegE {ECO:0000313|EMBL:CAQ89656.1};
GN OrderedLocusNames=EFER_2153 {ECO:0000313|EMBL:CAQ89656.1};
OS Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585054 {ECO:0000313|EMBL:CAQ89656.1, ECO:0000313|Proteomes:UP000000745};
RN [1] {ECO:0000313|Proteomes:UP000000745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 /
RC JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73
RC {ECO:0000313|Proteomes:UP000000745};
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CU928158; CAQ89656.1; -; Genomic_DNA.
DR RefSeq; WP_000042965.1; NC_011740.1.
DR AlphaFoldDB; B7LV31; -.
DR GeneID; 75056813; -.
DR KEGG; efe:EFER_2153; -.
DR HOGENOM; CLU_000445_126_1_6; -.
DR OrthoDB; 9787514at2; -.
DR Proteomes; UP000000745; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 3.
DR Gene3D; 2.10.70.100; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR007895; MASE1.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF05231; MASE1; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 3.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 300..370
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 374..426
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 501..552
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 553..605
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 626..680
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 712..845
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 855..1104
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1105 AA; 124154 MW; 6DFE3F13D2E5A9C7 CRC64;
MSKPSQHVLV TLPHPLLHLV SLGLVSFIFT LFSLELSQFG NQLAPLWFPT SIMMVAFYRH
AGRMWPGIAL TCSLGNIAAS VLLFSTSSLN MIWTGINIVE AATGALLLRK LLPWYNPLKN
LNDWLRLAFG SAIVPPLLGG VLILLITPGD DPLRSFFIWV LSESIGALAL VPLGLLFKPH
YLLRHRNPRL LFESLLTLAI TLTLSWLSML YLPWPFTFII VLLMWSAVRL PRMEAFLIFL
TTVMMVSLMM AADPSLLATP RTYLMSHMPW LPFLLILLPA NIMTMVMYAF RAERKHISES
ETRFRNAMEY SAIGMALVGT EGQWLQTNKA LCQFLGYNQD ELRALTFQQL TWPEDLNKDL
QQVEKLINGE INTYSMEKRY YNRTGDIVWA LLAVSLVRHT DGTPLYFIAQ IEDINELKRT
EHINKRLMER ITLANEAGGI GIWEWELKPD IFSWDKRMFE LYEIPPHIKP NWQVWYECVL
PEDRQHAEKV IRDSLQSRSP FKLEFRIAVK DGIRHIRALA NRVLNKEGEV ERLLGINMDM
TEVKQLNEAL FQEKERLHIT LDSIGEAVVC IDMAMKITFM NPVAEKMSGW MQEEALGVPL
LTVLHITFGD NGPLMENIYS ADTSRSAIEQ DVVLHCRSGG SYDVHYSITP LSTLDGSNIG
SVLVIQDVTE SRKMLRQLSY SASHDALTHL ANRASFEKQL RILLQTVNST HQRHALVFID
LDRFKAVNDS AGHAAGDALL RELASLMLSM LRSSDVLARL GGDEFGLLLP DCNVESARFI
ATRIISAVND YHFIWEGRVH RVGASAGITL IDDNNHQAVE VMSQADIACY ASKNGGRGRV
TVYEPQQADA HIERAAMSID EQWRMIKENQ LMMIAHGVAS PRIPEARNLW LISLKLWGCE
GEIFDEQTFR RSFGDPALNH ALDRRVLHEF FQQTAKAIAS KGLSIALPLS VAGLSSAALV
NELLEQLENS PLPPRLLHLI IPAEAVIDHA ESVQKLRLAG CRIVLSQVGR DLQIFNTLKA
NMADYLLLDG ELCASVQGNL MDEMLITIIQ GHAQRLGVKT IAGPVVLPLV MDTLSGIGVD
LIYGDVIADA QPLDLLVNNS YFAIN
//
