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Database: UniProt
Entry: B7MC05_ECO45
LinkDB: B7MC05_ECO45
Original site: B7MC05_ECO45 
ID   B7MC05_ECO45            Unreviewed;       481 AA.
AC   B7MC05;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=Peptidase {ECO:0000313|EMBL:CAR04846.1};
GN   Name=tldD {ECO:0000313|EMBL:CAR04846.1};
GN   OrderedLocusNames=ECS88_3620 {ECO:0000313|EMBL:CAR04846.1};
OS   Escherichia coli O45:K1 (strain S88 / ExPEC).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585035 {ECO:0000313|EMBL:CAR04846.1, ECO:0000313|Proteomes:UP000000747};
RN   [1] {ECO:0000313|Proteomes:UP000000747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S88 / ExPEC {ECO:0000313|Proteomes:UP000000747};
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Metalloprotease involved in CcdA degradation. Suppresses the
CC       inhibitory activity of the carbon storage regulator (CsrA).
CC       {ECO:0000256|ARBA:ARBA00025682}.
CC   -!- SIMILARITY: Belongs to the peptidase U62 family.
CC       {ECO:0000256|ARBA:ARBA00005836}.
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DR   EMBL; CU928161; CAR04846.1; -; Genomic_DNA.
DR   RefSeq; WP_000055911.1; NC_011742.1.
DR   AlphaFoldDB; B7MC05; -.
DR   KEGG; ecz:ECS88_3620; -.
DR   HOGENOM; CLU_026425_1_0_6; -.
DR   OMA; TDFWGSM; -.
DR   Proteomes; UP000000747; Chromosome.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR   PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR   Pfam; PF01523; PmbA_TldD_1st; 1.
DR   Pfam; PF19290; PmbA_TldD_2nd; 1.
DR   Pfam; PF19289; PmbA_TldD_3rd; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000747}.
FT   DOMAIN          37..98
FT                   /note="Metalloprotease TldD/E N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01523"
FT   DOMAIN          125..238
FT                   /note="Metalloprotease TldD/E central"
FT                   /evidence="ECO:0000259|Pfam:PF19290"
FT   DOMAIN          246..479
FT                   /note="Metalloprotease TldD/E C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19289"
SQ   SEQUENCE   481 AA;  51364 MW;  4863864B0965FED1 CRC64;
     MSLNLVSEQL LAANGLKHQD LFAILGQLAE RRLDYGDLYF QSSYHESWVL EDRIIKDGSY
     NIDQGVGVRA ISGEKTGFAY ADQISLLALE QSAQAARTIV RDSGDGKVQT LGAVEHSPLY
     TSVDPLQSMS REEKLDILRR VDKVAREADK RVQEVTASLS GVYELILVAA TDGTLAADVR
     PLVRLSVSVL VEEDGKRERG ASGGGGRFGY EFFLADLDGE VRADAWAKEA VRMALVNLSA
     VAAPAGTMPV VLGAGWPGVL LHEAVGHGLE GDFNRRGTSV FSGQVGELVA SELCTVVDDG
     TMVDRRGSVA IDDEGTPGQY NVLIENGILK GYMQDKLNAR LMGMTPTGNG RRESYAHLPM
     PRMTNTYMLP GKSTPQEIIE SVEYGIYAPN FGGGQVDITS GQFVFSTSEA YLIENGKVTK
     PVKGATLIGS GIETMQQISM VGNDLKLDNG VGVCGKEGQS LPVGVGQPTL KVDNLTVGGT
     A
//
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