ID   B7MKK1_ECO45            Unreviewed;       322 AA.
AC   B7MKK1;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein {ECO:0000313|EMBL:CAR04241.1};
GN   Name=hypE {ECO:0000313|EMBL:CAR04241.1};
GN   OrderedLocusNames=ECS88_2995 {ECO:0000313|EMBL:CAR04241.1};
OS   Escherichia coli O45:K1 (strain S88 / ExPEC).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585035 {ECO:0000313|EMBL:CAR04241.1, ECO:0000313|Proteomes:UP000000747};
RN   [1] {ECO:0000313|Proteomes:UP000000747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S88 / ExPEC {ECO:0000313|Proteomes:UP000000747};
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- SIMILARITY: Belongs to the HypE family.
CC       {ECO:0000256|ARBA:ARBA00006243}.
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DR   EMBL; CU928161; CAR04241.1; -; Genomic_DNA.
DR   AlphaFoldDB; B7MKK1; -.
DR   KEGG; ecz:ECS88_2995; -.
DR   HOGENOM; CLU_049733_0_0_6; -.
DR   Proteomes; UP000000747; Chromosome.
DR   CDD; cd02197; HypE; 1.
DR   Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR   Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR   InterPro; IPR011854; HypE.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   NCBIfam; TIGR02124; hypE; 1.
DR   PANTHER; PTHR30303:SF0; CARBAMOYL DEHYDRATASE HYPE; 1.
DR   PANTHER; PTHR30303; HYDROGENASE ISOENZYMES FORMATION PROTEIN HYPE; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   PIRSF; PIRSF005644; Hdrgns_mtr_HypE; 1.
DR   SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR   SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000747}.
FT   DOMAIN          29..138
FT                   /note="PurM-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00586"
FT   DOMAIN          152..300
FT                   /note="PurM-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02769"
SQ   SEQUENCE   322 AA;  33685 MW;  95E9362A7AF7490F CRC64;
     MQQLINSLFM EAFANPWLAE QEDQARLDLA QLVAEGDRLA FSTDSYVIDP LFFPGGNIGK
     LAICGTANDV AVSGAIPRYL SCGFILEEGL PMETLKAVVT SMAETARAAG IAIVTGDTKV
     VQRGAADKLF INTAGMGAIP ANIHWGAQTL TAGDVLLVSG TLGDHGATIL NLREQLGLDG
     ELVSDCAVLT PLIQTLRDIP GVKALRDATR GGVNAVVHEF AAACGCGIEL SEAALPVKPA
     VRGVCELLGL DALNFANEGK LVIAVERNAA EQVLAALHSH PLGKDAALIG EVVERKGVRL
     AGLYGVKRTL DLPHAEPLPR IC
//