ID GLPK_ECO7I Reviewed; 502 AA.
AC B7NU81;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 01-MAY-2013, entry version 31.
DE RecName: Full=Glycerol kinase;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase;
DE AltName: Full=Glycerokinase;
DE Short=GK;
GN Name=glpK; OrderedLocusNames=ECIAI39_3070;
OS Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAI39 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A.,
RA Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M.,
RA Dossat C., Karoui M.E., Frapy E., Garry L., Ghigo J.M., Gilles A.M.,
RA Johnson J., Le Bouguenec C., Lescat M., Mangenot S.,
RA Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A.,
RA Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B.,
RA Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC metabolism (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC phosphate.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR EMBL; CU928164; CAR19189.1; -; Genomic_DNA.
DR RefSeq; YP_002409000.1; NC_011750.1.
DR ProteinModelPortal; B7NU81; -.
DR SMR; B7NU81; 3-501.
DR STRING; 585057.ECIAI39_3070; -.
DR PRIDE; B7NU81; -.
DR EnsemblBacteria; CAR19189; CAR19189; ECIAI39_3070.
DR GeneID; 7151541; -.
DR KEGG; ect:ECIAI39_3070; -.
DR PATRIC; 18334976; VBIEscCol51957_3182.
DR eggNOG; COG0554; -.
DR HOGENOM; HOG000222134; -.
DR KO; K00864; -.
DR OMA; ALYGQLC; -.
DR ProtClustDB; PRK00047; -.
DR BioCyc; ECOL585057:GJ8I-3186-MONOMER; -.
DR UniPathway; UPA00618; UER00672.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR HAMAP; MF_00186; Glycerol_kin; 1; -.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR PANTHER; PTHR10196:SF9; PTHR10196:SF9; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Transferase.
FT CHAIN 1 502 Glycerol kinase.
FT /FTId=PRO_1000118550.
FT NP_BIND 412 416 ATP (By similarity).
FT BINDING 14 14 Substrate (By similarity).
FT BINDING 18 18 ATP (By similarity).
FT BINDING 84 84 Substrate (By similarity).
FT BINDING 136 136 Substrate (By similarity).
FT BINDING 246 246 Substrate (By similarity).
FT BINDING 268 268 ATP (By similarity).
FT BINDING 311 311 ATP; via carbonyl oxygen (By similarity).
SQ SEQUENCE 502 AA; 56215 MW; 260020C5DE2551D6 CRC64;
MTEKKYIVAL DQGTTSSRAV VMDHDANIIS VSQREFEQIY PKPGWVEHDP MEIWATQSST
LVEVLAKADI SADQIAAIGI TNQRETTIVW EKETGKPIYN AIVWQCRRTA EICEHLKRDG
LEDYIRSNTG LVIDPYFSGT KVKWILDHVE GSRERARRGE LLFGTVDTWL IWKMTQGRVH
VTDYTNASRT MLFNIHTLDW DDKMLEVLDI PREMLPEVRR SSEVYGQTNI GGKGGTRIPI
SGIAGDQQAA LFGQLCVKEG MAKNTYGTGC FMLMNTGEKA VKSENGLLTT IACGPTGEVN
YALEGAVFMA GASIQWLRDE MKLINDAYDS EYFATKVQNT NGVYVVPAFT GLGAPYWDPY
ARGAIFGLTR GVNANHIIRA TLESIAYQTR DVLEAMQADS GIRLHALRVD GGAVANNFLM
QFQSDILGTR VERPEVREVT ALGAAYLAGL AVGFWQNLDE LQEKAVIERE FRPGIETTER
NYRYAGWKKA VKRAMAWEEH DE
//
