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Database: UniProt
Entry: B7P170_IXOSC
LinkDB: B7P170_IXOSC
Original site: B7P170_IXOSC 
ID   B7P170_IXOSC            Unreviewed;       551 AA.
AC   B7P170;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   25-OCT-2017, entry version 65.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEC00342.1, ECO:0000313|VectorBase:ISCW016113-PA};
GN   Name=8023351 {ECO:0000313|VectorBase:ISCW016113-PA};
GN   ORFNames=IscW_ISCW016113 {ECO:0000313|EMBL:EEC00342.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945 {ECO:0000313|Proteomes:UP000001555};
RN   [1] {ECO:0000313|EMBL:EEC00342.1, ECO:0000313|Proteomes:UP000001555, ECO:0000313|VectorBase:ISCW016113-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555,
RC   ECO:0000313|VectorBase:ISCW016113-PA}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC00342.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M.,
RA   Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J.,
RA   Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G.,
RA   Meyer J., Hill C.A., Birren B., Nene V., Collins F.,
RA   Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|VectorBase:ISCW016113-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|VectorBase:ISCW016113-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; ABJB010344775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010382518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010467218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010474531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010638971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010781682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010789358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB011110304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB011113817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS615069; EEC00342.1; -; Genomic_DNA.
DR   RefSeq; XP_002400556.1; XM_002400512.1.
DR   UniGene; Isc.11130; -.
DR   EnsemblMetazoa; ISCW016113-RA; ISCW016113-PA; ISCW016113.
DR   GeneID; 8023351; -.
DR   KEGG; isc:IscW_ISCW016113; -.
DR   VectorBase; ISCW016113-RA; ISCW016113-PA; ISCW016113.
DR   CTD; 8023351; -.
DR   eggNOG; ENOG410INF7; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   InParanoid; B7P170; -.
DR   KO; K16896; -.
DR   OrthoDB; EOG091G038K; -.
DR   PhylomeDB; B7P170; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF231; PTHR10037:SF231; 3.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001555};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    151    170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    214    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    247    268       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    390    415       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      351    386       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND     364    375       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   551 AA;  64014 MW;  D3190FED4729FC3D CRC64;
     MVYGYWDGVD VPYDLSNSEE LTRSHNTELN SPCGEIPPDR LAKCWQLNYH EAAIFLEEGQ
     NNDKLDFHPC SHAALPAYLV VHNRLFYCLD LLSAVVLMSL ALMEEPALPG LDVPIAFHVA
     VELLALCVVA AELVMKLRWL GLRPFFAHKR TVFKLTILLL MFVEALVVAA RQTNHFRVLR
     ALRPIFLIDN HYLGGVRRLT RQILQSLPPV FDMLVILFFF MTMFAILAYH MFAAAPEQYF
     STLYDSFMNL FVLLTTSNFP DVMIPYYARS KWASLFFVVF LLVHLYFLMN LVLAVVYERF
     SSLEKDKFRK LLLHRRKACQ QAFRLLVNRT SPSCLYFCHF EGLMRYYKPR AKRREVYLMF
     KTMDVSRNGF LSQEDFLQVL FQLKKSYHDV LGTVFILMPR FLSVGLVLIV VYYFFAIIGI
     EVFSGYQMED CCNRHLASLH PPEDNLVRVE TRMSKAEIAL CSDPTPHPPA PEPLNYATDA
     AADTLVFRGV RWRTKFSFCL KMYAEEVKEW LDHAELEERR SNEWLILNVQ NREGDSTALE
     AGHESRRTFT L
//
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