ID B7P177_IXOSC Unreviewed; 468 AA.
AC B7P177;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Iroquois-class homeobox protein IRX, putative {ECO:0000313|EMBL:EEC00349.1, ECO:0000313|EnsemblMetazoa:ISCW015741-PA};
GN ORFNames=IscW_ISCW015741 {ECO:0000313|EMBL:EEC00349.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC00349.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC00349.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW015741-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW015741-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR EMBL; ABJB010038895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010166802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010354557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010669759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010683897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010788531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010797395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011109591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011122198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS615078; EEC00349.1; -; Genomic_DNA.
DR RefSeq; XP_002400564.1; XM_002400520.1.
DR AlphaFoldDB; B7P177; -.
DR STRING; 6945.B7P177; -.
DR PaxDb; 6945-B7P177; -.
DR EnsemblMetazoa; ISCW015741-RA; ISCW015741-PA; ISCW015741.
DR KEGG; isc:IscW_ISCW015741; -.
DR VEuPathDB; VectorBase:ISCI015741; -.
DR VEuPathDB; VectorBase:ISCP_038232; -.
DR VEuPathDB; VectorBase:ISCW015741; -.
DR HOGENOM; CLU_584339_0_0_1; -.
DR InParanoid; B7P177; -.
DR OMA; MEERTSI; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211:SF40; HOMEOBOX PROTEIN ARAUCAN-RELATED; 1.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 15..78
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 17..79
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 79..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 49252 MW; 5C4580935D54B7DF CRC64;
MIRAHWTKLR YGGLDFNGAR RKNVTRDSTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT
LTQVSTWFAN ARRRLKKENK MTWEPRNKAD ADDSGEDKKD DEDTMEERTS IAQDPMRRTE
SSRSYCSLSS LQHSRDSTLR PPQTSVEVER EPAELQTTQP HPSNAAMEQQ QQQRHGYGHS
MNPYAVGGTS RSPILSGIMS LAPPNALTGY TPAASSDSPS PDLQGLESLM SKSSPNAADD
SSGADNSHSK PKIWSLADTA TSKSPPPPLP CAAVQPSGHQ THGTPKEAAA ATGNHGSVLG
WFSGGYHHHR GGTPTSGHFG GYASNGFSPG ATAPQTDTPP QTPPNAKMNA TGASSSIPFH
LGSGGYFQGQ GCPSHLYLGQ ASSGGGHPQM SVDKSSSVSC AGGPVPIYRA GAGYAVASSA
PAAIMAAAGS PCADAGSSSS NSSSSEDEFA QQHYGTGTPV DAMADAMP
//
