ID   B7P2K6_IXOSC            Unreviewed;       928 AA.
AC   B7P2K6;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   RecName: Full=MBD domain-containing protein {ECO:0000259|PROSITE:PS50982};
GN   ORFNames=IscW_ISCW000867 {ECO:0000313|EMBL:EEC00828.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC00828.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC00828.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW000867-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000867-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; ABJB010454097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010687154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS622764; EEC00828.1; -; Genomic_DNA.
DR   RefSeq; XP_002402466.1; XM_002402422.1.
DR   AlphaFoldDB; B7P2K6; -.
DR   STRING; 6945.B7P2K6; -.
DR   PaxDb; 6945-B7P2K6; -.
DR   EnsemblMetazoa; ISCW000867-RA; ISCW000867-PA; ISCW000867.
DR   KEGG; isc:IscW_ISCW000867; -.
DR   VEuPathDB; VectorBase:ISCI000867; -.
DR   VEuPathDB; VectorBase:ISCP_019145; -.
DR   VEuPathDB; VectorBase:ISCW000867; -.
DR   HOGENOM; CLU_306353_0_0_1; -.
DR   InParanoid; B7P2K6; -.
DR   OMA; CPVMVVE; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   CDD; cd00122; MBD; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   PANTHER; PTHR15739:SF5; LD23158P; 1.
DR   PANTHER; PTHR15739; ZINC FINGER PROTEIN; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF01429; MBD; 1.
DR   SMART; SM00391; MBD; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50982; MBD; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B7P2K6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT   DOMAIN          3..75
FT                   /note="MBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50982"
FT   REGION          294..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..349
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..405
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  100685 MW;  998322F3D4C250AD CRC64;
     MKSQDMEPLL KPFEYGFKRE LVHRATSNQK VAADVYYYDS AGLKMRSIPD VVTYLGKHPE
     INLAAANFSF RRVTIHKPPH EVVRQAKAGV RTAPVTPPSV LNACDLLEGP VLKELDEPAT
     VSPKGVPTTI VKVTPAHRHD MELPHHQQKL PKDRWKLGNQ SLLRTGASLE LCNLHCAQAK
     GQFPSLQCPK CLCLFHPVCV KGDDGEGFVC KQLNQRPSAT LQPTMMPASG DAPPGSDLVI
     DMDEKPVCQG VDKAVESSIV RTYAADGSGS VVSTSTVSCP LLLVDIDSLE TDRQQTCTHS
     NGTSSPDRSS SRANVDETAQ GDRKSPSMLE LMLKNSDGDE ERPGVTKRES DLSFVETPTL
     ASDVEKPTVS VSATTSDGCL NRDSRAKNSD QKREPSRCRK LSSRERAASR LLQGLSRLCE
     HPNGAAARIH LKKPRHSATL PEVATPLSDS EFDGADGTED ASAQERCNSR LGGVATASEV
     PGKAGELPFW VVTPTNTVCV GSEVCPVPAE SVRQAGNRGG SGSASLAGVS FGPSILNRIF
     SFLPVAALCR VATVCWGWNL LSKHPNLWGQ VDLRGVNVTD WDTCTLVLQQ RQTHTLVVKG
     SSSSHLVPWV KRLDWVQSLS LYGGSLADLA TLVKLFPQMT SLNAVQLTRP QQCRGDDARR
     ESVLLGELQA LVGMPRLRSL RLSSMGGLLL CPWAVPKEAG EQRFLALRTL SMTTLRCSSL
     EAFVSLKCLP HLEDLELGDC ASWTNQSYLE LGQLPKLKCL SLIRGQDQPC FRYVLLKLVH
     LEVLRLKRWT FRGSIGQLLA QLPRLRQLLL WPQARDLATN NVHALRSCLG LSTLQRLSWV
     IDCGGSVSCS LASGLEIPVA SGRLCDCKAS QLLSSQADNP CGCRLLEESL EGEEGTSMRW
     LTAGQLSGIL ARSLGAGTAV CVSLRVGF
//