ID B7P2W7_IXOSC Unreviewed; 843 AA.
AC B7P2W7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE SubName: Full=NAD dehydrogenase, putative {ECO:0000313|EMBL:EEC00939.1, ECO:0000313|EnsemblMetazoa:ISCW000984-PA};
DE EC=1.5.99.1 {ECO:0000313|EMBL:EEC00939.1};
GN ORFNames=IscW_ISCW000984 {ECO:0000313|EMBL:EEC00939.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC00939.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC00939.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW000984-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000984-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; ABJB010600073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS624854; EEC00939.1; -; Genomic_DNA.
DR RefSeq; XP_002403091.1; XM_002403047.1.
DR AlphaFoldDB; B7P2W7; -.
DR STRING; 6945.B7P2W7; -.
DR PaxDb; 6945-B7P2W7; -.
DR EnsemblMetazoa; ISCW000984-RA; ISCW000984-PA; ISCW000984.
DR KEGG; isc:IscW_ISCW000984; -.
DR VEuPathDB; VectorBase:ISCI000984; -.
DR VEuPathDB; VectorBase:ISCP_013927; -.
DR VEuPathDB; VectorBase:ISCW000984; -.
DR HOGENOM; CLU_007884_11_0_1; -.
DR InParanoid; B7P2W7; -.
DR OMA; PFNVQRF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF193; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase {ECO:0000313|EMBL:EEC00939.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P2W7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 11..365
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 370..424
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 429..698
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 728..816
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 843 AA; 94105 MW; 52E272ED5B60A3BA CRC64;
MSERVLPKLA RVVICGAGVV GNSIAYHLVK RGWTDLVVLE KGRIGCGATW RSSGLAGQLH
PTVNGIIARS SVKLYDSLQR EGHDIGWQQC GTLSVARTRK RMVSLQRLAA EARARGVDCT
VHQPQSLKEL HPFLRTEDLA GGVFVPGDGV VDTEALCQTL AKLAQEGGAQ YVEECQVHRV
LSHEGTVVGA DTELGTINCE YFILAGGMWS RELAQASQPK FSVPIHAAKH SFGVTKPLDD
TDRSLPVVWD YDGRVYSRTF GRGFLVGGFE ETAKPLFHYD VPDKFEFLRL APDYPQFKSI
YEQFQHRFPD LRHLELAELV TAPETFTPDN HCILGETSEV EGLFLAVGMN GAQAQSAGGV
GRALALWLCD GAPRAYLLPC DCRRFLDLHN NAKFLRERVT EARPTEPDAR VQAEFRTGRR
LRCSPLLPLQ EQQGAVLGER MGFERALFFD TQHESGERQL SASPTYGQPD WLELVHQEYV
ACRERVGISD MSSFTKFYLE SGGLEVVSLL QMLCSNEVDV PVGHIVQTGM QNDRGGYEND
CILVRMDANR YFMVSPTAQQ TRIAKWVRRH LPRDGSVSLR DVTSLYTVLY VLGPKSRSLL
EEVTGREIDL EPFTCQEMDV AYATNVLVLG YNNTLEPGYS LYIPSEYAQH VYGRLKKAGR
DYGVLDVGYY ALRMLRIEKF VPFWAEELDS SVTPLEANRS ARVKLQKEPA FIGQAALQQQ
AREGLRRQLA FFQLGGEHDC ERDPWAWGQE PLFCEGRFVG LTSSGSYAFS LAKNVCQGFV
HWFDPGSRQL QLLPPGLISQ GRFEVELAGR RFPVEASVVA PKLTVAPMGG VRDRYKPQAR
TLL
//
