ID B7P4W6_IXOSC Unreviewed; 613 AA.
AC B7P4W6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Serine protease, putative {ECO:0000313|EMBL:EEC01638.1, ECO:0000313|EnsemblMetazoa:ISCW001620-PA};
DE EC=3.4.21.4 {ECO:0000313|EMBL:EEC01638.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW001620 {ECO:0000313|EMBL:EEC01638.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC01638.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC01638.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW001620-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW001620-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010162550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010195244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010438186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010654366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010728001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS637221; EEC01638.1; -; Genomic_DNA.
DR RefSeq; XP_002406522.1; XM_002406478.1.
DR AlphaFoldDB; B7P4W6; -.
DR STRING; 6945.B7P4W6; -.
DR PaxDb; 6945-B7P4W6; -.
DR EnsemblMetazoa; ISCW001620-RA; ISCW001620-PA; ISCW001620.
DR KEGG; isc:IscW_ISCW001620; -.
DR VEuPathDB; VectorBase:ISCI001620; -.
DR VEuPathDB; VectorBase:ISCP_020080; -.
DR VEuPathDB; VectorBase:ISCW001620; -.
DR HOGENOM; CLU_445926_0_0_1; -.
DR InParanoid; B7P4W6; -.
DR OMA; EMASSRW; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24253:SF161; SERINE PROTEASE FILZIG; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EEC01638.1};
KW Protease {ECO:0000313|EMBL:EEC01638.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 420..613
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 31..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..339
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC01638.1"
SQ SEQUENCE 613 AA; 67104 MW; 9783F69A692F086C CRC64;
EGTMLAACMD GFLLGACCKL PEEVNATTVS WTEHSTHTTS EASKDSGDPE TTTSEYTSSW
SEHHLPEASR LPLSTTTEAP STPPSTVMRP TTLVARPTTL WPFIRLPTTL KRPTIVQTST
SQGTATVNNH HRPPTIATPL VTAWMTTRPA MIFTPTRLTL RPPHLPSTPL YVQRPSLQAV
LANTPIGILG SLLTRPFTRP MTRPVTSAMF SRPQTVSILP SKTHSPLTTP MQSDSPTKNP
QRHEVASTEP PTQTTALEPF TSRPPITTLQ TLRPPATTQV YRPTYYTTLK FPVSTKKPAP
GTGKPVKTTQ PMTAATKPKS TPKPVKPILP IPSRPVKPTK APVPTKSSTK KTTPRPAPSR
LPAQSPTTSW PSGSTLTTKQ KLPVKGTTVN GSVTPTETSP LRWDYRKHCG VRPLRPQGRI
VGGRNSFFGE WPWQVLVKEA TWLGLFIKNK CGGVLISSKY ALTAAHCQPG FLSSLLVVLG
EHDLSGDYET MKPVSVPVRR MVVHRNYNPA TFENDLALLE LERPVTFQPH IVPICLPGKN
EDFTGRTSYV TGWGKLSHGG SVPNVLQYVQ VPILSNNRCQ KMFMLAGHVK AIRDNFVCAG
YDRGNRDSCE VRS
//
