ID   B7P5B9_IXOSC            Unreviewed;       627 AA.
AC   B7P5B9;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=Rab9 effector protein with kelch motifs {ECO:0000256|ARBA:ARBA00039295};
GN   ORFNames=IscW_ISCW015857 {ECO:0000313|EMBL:EEC01791.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC01791.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC01791.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW015857-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW015857-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- FUNCTION: Rab9 effector required for endosome to trans-Golgi network
CC       (TGN) transport. {ECO:0000256|ARBA:ARBA00037224}.
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DR   EMBL; ABJB010138460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010269215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010575574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS640098; EEC01791.1; -; Genomic_DNA.
DR   RefSeq; XP_002407231.1; XM_002407187.1.
DR   AlphaFoldDB; B7P5B9; -.
DR   STRING; 6945.B7P5B9; -.
DR   PaxDb; 6945-B7P5B9; -.
DR   EnsemblMetazoa; ISCW015857-RA; ISCW015857-PA; ISCW015857.
DR   KEGG; isc:IscW_ISCW015857; -.
DR   VEuPathDB; VectorBase:ISCI015857; -.
DR   VEuPathDB; VectorBase:ISCP_022977; -.
DR   VEuPathDB; VectorBase:ISCW015857; -.
DR   HOGENOM; CLU_436334_0_0_1; -.
DR   InParanoid; B7P5B9; -.
DR   OMA; LETHHEF; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   PANTHER; PTHR46647; RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS; 1.
DR   PANTHER; PTHR46647:SF1; RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF13415; Kelch_3; 1.
DR   SUPFAM; SSF117281; Kelch motif; 1.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          301..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   627 AA;  67697 MW;  C61ECDC64B8163CB CRC64;
     MPPHPSQQQQ QPRYTEQWEL LSGGCAAVVG GGGNNGGHNG GWTDGSAAAE LGPAPRHSHT
     CIVHQGAMWI YGGLADLQER SDFWSYHFET GRWSRVRPSK GGPGELHGHA AVQAPGCMYL
     FGGEHQGTAN NDLWRFHFAS ETWEKVVVEG NAPTPRCRHV ALVNPSMPTW ADRVRPSAAD
     VDADGLWSAS QAASAGDGHP RRASFRFKVH PVSRLCSKRT GSQDEDEDRY AYGAQLASQV
     NLRSLKEKLS SSRLVRSISS GNYGVGIVRR DELQNLLDGG DSSAGGTPNL QPSTAIQKSL
     SSDAVLEPSD SEPSTPRHQL HIAVRPLSEI LPRNRDEDVV PGRLSPPPQS GRSRRMTSSQ
     SLTTFSARGH NAVAPAVLGG GSCCCSPTTA TTSPQEHQHS PCENDVGSMK APATADRSDL
     LIDLESRSSA KLRQARRSTS SYTSFSTLSD GTGGSCLQTP VVELSHSVSH CSGYYSFAED
     DPELQRDIVN FLTGNGPRTS RPVSLNAGRS SEDSAVLEMN TFSVAAQPGI QVVKQRAKSW
     DRVSQRVPSG SSTAVVLRGS GQPRTHLIQA IKEESCHGTP VRVKLSSPSR ARPEQHRWRL
     CFYVFGGSEQ GAPGMYRQPI SIWQLYI
//