ID B7P6P2_IXOSC Unreviewed; 167 AA.
AC B7P6P2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW001004 {ECO:0000313|EMBL:EEC02264.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02264.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02264.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW001004-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW001004-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010731766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010974227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS647014; EEC02264.1; -; Genomic_DNA.
DR RefSeq; XP_002409050.1; XM_002409006.1.
DR AlphaFoldDB; B7P6P2; -.
DR STRING; 6945.B7P6P2; -.
DR PaxDb; 6945-B7P6P2; -.
DR EnsemblMetazoa; ISCW001004-RA; ISCW001004-PA; ISCW001004.
DR KEGG; isc:IscW_ISCW001004; -.
DR VEuPathDB; VectorBase:ISCI001004; -.
DR VEuPathDB; VectorBase:ISCW001004; -.
DR HOGENOM; CLU_1598639_0_0_1; -.
DR InParanoid; B7P6P2; -.
DR OMA; YIVIWEK; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC02264.1"
FT NON_TER 167
FT /evidence="ECO:0000313|EMBL:EEC02264.1"
SQ SEQUENCE 167 AA; 18284 MW; DDB1F810B837E6DE CRC64;
VPPNTGRNML GVLDETQSLE YGEVFVQFTE HQLDDGSCED DPKVPTTKIL VGAVLVTKCP
CLHPGDVRKF AAVDIPGLHH VKDCIVFPAK GPRPHPNEMA GSDLDGDEYI VIWEKDLLFP
GNNQPAMVFC DHSSVVPSDD SLEDGMVKFI CNYIKNDNVG ILSNAHL
//
