ID B7P853_IXOSC Unreviewed; 295 AA.
AC B7P853;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|Pfam:PF00060};
GN ORFNames=IscW_ISCW002839 {ECO:0000313|EMBL:EEC02775.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02775.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02775.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW002839-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW002839-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; ABJB010347874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010574061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010846938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS655766; EEC02775.1; -; Genomic_DNA.
DR RefSeq; XP_002401236.1; XM_002401192.1.
DR AlphaFoldDB; B7P853; -.
DR PaxDb; 6945-B7P853; -.
DR EnsemblMetazoa; ISCW002839-RA; ISCW002839-PA; ISCW002839.
DR KEGG; isc:IscW_ISCW002839; -.
DR VEuPathDB; VectorBase:ISCI002839; -.
DR VEuPathDB; VectorBase:ISCP_003113; -.
DR VEuPathDB; VectorBase:ISCW002839; -.
DR HOGENOM; CLU_068752_0_0_1; -.
DR InParanoid; B7P853; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF39; LIG_CHAN-GLU_BD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..295
FT /note="Ionotropic glutamate receptor C-terminal domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014567935"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..269
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 295 AA; 32656 MW; 79DB05364F91D11F CRC64;
MFLSAALLVT TLLTGIARSF YGTKRWTWRS FLGNLGDALW MYLENLFMEG SATPPRRSVL
RLLSSVWWLA TIVLMNAFCG HMRACLMIKS EVKKINSVRE LAQKPTVQPY MWKGTSYVGM
LARSTNEDMR KISRVVEEKG TALPVSILYG EALLKRVVQG RAAVISDGTS LVYRVSNVCG
AFRDSEFYLA EEGLVSHPLN SFLRKDVDPE FHAGVNRVIR RLVEAGLVDH WWTAGTGDIS
RCGGSIQQDS ATTLALSDLR GIFVLWLVSL GFAGTAFCCE LGMTSVHALD QSSGQ
//
