ID B7P8B1_IXOSC Unreviewed; 338 AA.
AC B7P8B1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Isocitrate dehydrogenase, putative {ECO:0000313|EMBL:EEC02833.1, ECO:0000313|EnsemblMetazoa:ISCW016729-PA};
DE EC=1.1.1.42 {ECO:0000313|EMBL:EEC02833.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW016729 {ECO:0000313|EMBL:EEC02833.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02833.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02833.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016729-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016729-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; ABJB010971034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS656447; EEC02833.1; -; Genomic_DNA.
DR RefSeq; XP_002401648.1; XM_002401604.1.
DR AlphaFoldDB; B7P8B1; -.
DR STRING; 6945.B7P8B1; -.
DR PaxDb; 6945-B7P8B1; -.
DR EnsemblMetazoa; ISCW016729-RA; ISCW016729-PA; ISCW016729.
DR KEGG; isc:IscW_ISCW016729; -.
DR VEuPathDB; VectorBase:ISCI017423; -.
DR VEuPathDB; VectorBase:ISCP_003247; -.
DR VEuPathDB; VectorBase:ISCW016729; -.
DR HOGENOM; CLU_031953_0_1_1; -.
DR InParanoid; B7P8B1; -.
DR OMA; WERHIAG; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006097; P:glyoxylate cycle; IEA:InterPro.
DR GO; GO:0006102; P:isocitrate metabolic process; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR014273; Isocitrate_DH_bac-typ.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR NCBIfam; TIGR02924; ICDH_alpha; 1.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF43; ISOCITRATE DEHYDROGENASE [NADP]; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEC02833.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 6..337
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
FT NON_TER 338
FT /evidence="ECO:0000313|EMBL:EEC02833.1"
SQ SEQUENCE 338 AA; 37596 MW; 47D77E85BC07A1A6 CRC64;
MAEFTPITIA YGDGIGPEIM EAVLYILCKA EVRIRLETIE VGEKLYKKHY TSGISEESWE
SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRS SVSFHPFIKT LHPNLNLTII
RENEEDLYAG IEYRQTYNMY ESVKLISRTG CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK
FSDGVFHKVF NEIAKEYPQI NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE
ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIATL
IENAWKKTIE DGIHTTDIYN EQSSSKKVGT KEFAEEVT
//