ID B7P8Q2_IXOSC Unreviewed; 1261 AA.
AC B7P8Q2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=ABC transporter, putative {ECO:0000313|EMBL:EEC02974.1, ECO:0000313|EnsemblMetazoa:ISCW017301-PA};
DE EC=3.6.3.28 {ECO:0000313|EMBL:EEC02974.1};
DE EC=3.6.3.38 {ECO:0000313|EMBL:EEC02974.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW017301 {ECO:0000313|EMBL:EEC02974.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02974.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02974.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW017301-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW017301-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ABJB010046251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010117990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010323350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010585798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010861510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011085955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS658625; EEC02974.1; -; Genomic_DNA.
DR RefSeq; XP_002402543.1; XM_002402499.1.
DR AlphaFoldDB; B7P8Q2; -.
DR PaxDb; 6945-B7P8Q2; -.
DR EnsemblMetazoa; ISCW017301-RA; ISCW017301-PA; ISCW017301.
DR KEGG; isc:IscW_ISCW017301; -.
DR VEuPathDB; VectorBase:ISCI017301; -.
DR VEuPathDB; VectorBase:ISCP_012637; -.
DR VEuPathDB; VectorBase:ISCP_026473; -.
DR VEuPathDB; VectorBase:ISCW017301; -.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; B7P8Q2; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:EEC02974.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P8Q2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 293..527
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC02974.1"
FT NON_TER 1261
FT /evidence="ECO:0000313|EMBL:EEC02974.1"
SQ SEQUENCE 1261 AA; 142567 MW; 30AA2960422BC4D3 CRC64;
EDVSTVRLQR FPYPSYIEET DVSNYALVLS RFSIGMLVPF AVFATRLTDE KTSGMKEMLR
IIGVSDWVYW ASHYLSAFFM HLITVTLMMI FLCIKRNDEG RSFIQRSDPF LVFCVLLNFC
SSCMLHAALL SLFFANREFT TDHAQIFDSR KFGKVNYCHG YHFITRGHKL WTCIFPGMNL
HWGFRVLNRF EKFVDSGANW SNFYDPKETP DNVTLFEIAT VGFLSDVLII VLVWYLDNVL
PIGPGISKPV GYPFMKSYWF PGMTSLKAVD KTDEEKLNFE TEPKNQVVAI ELLQVNKVSK
KIIPQNYKDT VAVSNCNMRV FEGQITVLLG HNGAGKTTTL NMITGYIDAT SGTILVGGYD
ILNATRDARK SVGYCAQHNI LYRDLTVEEH LLFFAAVKGA PRDRLRLELV TLLGEVGLME
VRNTLAALLS PGFQRRLCMA LAIIATPKLV VLDEPTANMD PDARREMWEL LLKVRRQSAV
LITTQHMDEA DVLGDRIAIM ANGRIRCMGS PAFLKQRFGT GYHMQVNKAA FCNVSAIESL
LRKYAPRARL QSDSDNEAVF VLGQIVTTRH TIAMFRDLEQ GKDKLGIESL GLTVTTLEDV
LMRVGEEHHF RRHHMHSDFD DENEFIEARG KSLFNVMADN ISSEPGLVQR IRALLAKRAI
CTWRQWRLPL FSWLLPPLLL FSLFYLEEVE NKHLKKRVFG IRYFNKPLIL LYILQRNFGF
NKIPPNGPRH SVYLPHYFLL CAHVHKRFLG RFNLEAKLDA VTLLIQSAPH RVLENSTKTQ
SAFVEKYLGP VLVEQSFKTD DIPADYNIAQ YLLGIAQHSL RHYIFDIHAG FQMTKQKGWV
SARQSTEGAL PLIERSNAVK HLHFMNGVSC LLYWSANFFW DFMFYLGTAL LVLPPLLSQL
DYLVGIDTQA IILLNLLHGF AVLPGIYITS FFFDNPIQGY STLAITAFIL SFLGCLGTVF
VEHFAYTINA PLVMVVLEVM LQAMLLVPSF SYSRGMTKIL ELSSENKICR TGGVNLERVC
HTHAIDFKLS LKLCCEGERS RSRNPPFLDG VKVKDAAHTR FVQPSFKHLH RLQVMLEDSD
AVRENALVDT LSGSVGRDAR PFGPDQRPAM VVSRLTKAYG WWQKKPVLQG LSFVLRTGEC
FGLLGVNGAG KTTTFRILTG DVLPADGDVF LDGFSIVRQT KLVQAHLGYC PQRDGLVDEL
TGTETLILHS RLKGVANDAD YLEVLFEIFD LADIAGNLVG TYSAGNKRKL SLCLAMVGMP
R
//
