ID B7P9C8_IXOSC Unreviewed; 308 AA.
AC B7P9C8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW003356 {ECO:0000313|EMBL:EEC03200.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03200.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03200.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW003356-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW003356-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361144};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|RuleBase:RU361144};
CC -!- SIMILARITY: Belongs to the peptidase M2 family.
CC {ECO:0000256|ARBA:ARBA00008139, ECO:0000256|RuleBase:RU361144}.
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DR EMBL; ABJB010189221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010270852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010742662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010954746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS662515; EEC03200.1; -; Genomic_DNA.
DR RefSeq; XP_002403946.1; XM_002403902.1.
DR AlphaFoldDB; B7P9C8; -.
DR PaxDb; 6945-B7P9C8; -.
DR EnsemblMetazoa; ISCW003356-RA; ISCW003356-PA; ISCW003356.
DR KEGG; isc:IscW_ISCW003356; -.
DR VEuPathDB; VectorBase:ISCI003356; -.
DR VEuPathDB; VectorBase:ISCP_023788; -.
DR VEuPathDB; VectorBase:ISCW003356; -.
DR HOGENOM; CLU_014364_3_3_1; -.
DR InParanoid; B7P9C8; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IBA:GO_Central.
DR GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR001548; Peptidase_M2.
DR PANTHER; PTHR10514; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR PANTHER; PTHR10514:SF27; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR Pfam; PF01401; Peptidase_M2; 2.
DR PRINTS; PR00791; PEPDIPTASEA.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|RuleBase:RU361144,
KW ECO:0000313|EMBL:EEC03200.1};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU361144};
KW Hydrolase {ECO:0000256|RuleBase:RU361144, ECO:0000313|EMBL:EEC03200.1};
KW Metal-binding {ECO:0000256|RuleBase:RU361144};
KW Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW Protease {ECO:0000256|RuleBase:RU361144};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|RuleBase:RU361144}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC03200.1"
SQ SEQUENCE 308 AA; 36391 MW; 6FC8B09351DC8F4E CRC64;
LVQIMSISEN YEERRYYWQQ WRRVAVEPSR KQFLDLLQLL DVEAKLNGFN STTEYWIYEY
EWETFHGDLE SLWELTKPLY EQLHAFLRNG LVLKYRAKYL QKMSVIDIFK LAESFYTSLG
LPPLPPAFWN NSVLEESPAE SKQICDASAW DFCDGRDFRW HKQMLFLNPY SSFAPCLPFW
TPYRIRMCTE KSLEGLKEVF HEMGHVYYFQ QYAGLPHVFR QGANPGFHEA VADAMAWLAC
SPQRLHKIGL LDRITKELDI GQLFDQALKY VVRIPSWIAS LNWMWHILNN AGVSDGGDME
ARYWALRP
//
