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Database: UniProt
Entry: B7PA36_IXOSC
LinkDB: B7PA36_IXOSC
Original site: B7PA36_IXOSC 
ID   B7PA36_IXOSC            Unreviewed;      1822 AA.
AC   B7PA36;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   30-AUG-2017, entry version 50.
DE   SubName: Full=Ryanodine receptor, putative {ECO:0000313|EMBL:EEC03458.1, ECO:0000313|VectorBase:ISCW017057-PA};
GN   Name=8026823 {ECO:0000313|VectorBase:ISCW017057-PA};
GN   ORFNames=IscW_ISCW017057 {ECO:0000313|EMBL:EEC03458.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945 {ECO:0000313|Proteomes:UP000001555};
RN   [1] {ECO:0000313|EMBL:EEC03458.1, ECO:0000313|Proteomes:UP000001555, ECO:0000313|VectorBase:ISCW017057-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555,
RC   ECO:0000313|VectorBase:ISCW017057-PA}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC03458.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M.,
RA   Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J.,
RA   Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G.,
RA   Meyer J., Hill C.A., Birren B., Nene V., Collins F.,
RA   Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|VectorBase:ISCW017057-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|VectorBase:ISCW017057-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; ABJB010169094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010239471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010348909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010500750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010518691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010568721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010636962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010752397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010842039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010937875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS668850; EEC03458.1; -; Genomic_DNA.
DR   RefSeq; XP_002406144.1; XM_002406100.1.
DR   STRING; 6945.ISCW017057-PA; -.
DR   EnsemblMetazoa; ISCW017057-RA; ISCW017057-PA; ISCW017057.
DR   GeneID; 8026823; -.
DR   KEGG; isc:IscW_ISCW017057; -.
DR   VectorBase; ISCW017057-RA; ISCW017057-PA; ISCW017057.
DR   CTD; 8026823; -.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   InParanoid; B7PA36; -.
DR   KO; K04962; -.
DR   OMA; ENETHEE; -.
DR   OrthoDB; EOG091G00T0; -.
DR   PhylomeDB; B7PA36; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001555};
KW   Receptor {ECO:0000313|EMBL:EEC03458.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT   DOMAIN      635    820       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1049   1247       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   1822 AA;  202616 MW;  2966AC900B053E08 CRC64;
     MSEEGKMDDG LEFSRAQVEE SRTARVIRKC GSLFNKFIVN LDAMQNEGAT EESAISTIDQ
     DEMIMCFEDL INYFVQPEDD IEHEEKQNKL KALRNRQDLF QEEGILNLIL ETIDKINTIT
     TSGYLMTAGG EDAGQNWDAI SGFLYQLLAA IIKGNHTNCA QFAQPHRLDW LFSRLSSQQA
     SEGTGMLDVL HCVLIDSPEA LNIMKEDHIK VIISLLEKHG RDPKVLDVLC SLCVTGKGVA
     VRSSQNNICD NLLPGRNLLL QTRLVDHHAA QHIRGAGGGG GPVPALVLRG HGGPLRAAEP
     PGAAPAHRVG QHGGLRALPG GRLQVGRQRP RGRPLLLRLR RGLPLDRCRC AGAAGGPAKW
     SGGTSVYPST HSRKLRIFTR RATFSTRSCR TPNVRACRFL LGGDQGKLRY GPPDGHSALV
     EALLPQQVLT VEPCFQFGDV PKGVLFGPAA ISDDAVFVPA PVDTSAIALP NYIESVRDKL
     AENIHEVWSM KKIDAGWRYA EVRDDNRNVH PCLTSFEHLP PAEKKYDTTL ALQTLKTILA
     LGYHITVDKP PARIKTIKLP NDPYLQSNGY KPAPLDVGAI SLTPKMEELV DLLSENTHNV
     WAQERIQHGW TYGLVEASPT RRSPHLVPYK TVDDIIKKAN RDTASELVRT LLAYGYVLEP
     PTADSLEGAQ SKVSSVKYDQ RTYRAERTYA VTDGKWYFEF EVLTLGVMKV GWAGPNFLPS
     CELGGDDNSW AFDGFKAAKN HAGGSEVYGK QWQIGDVIGC MLDLHDRTIS FSLNGELLLD
     SLGGETAFSD IPCGEGASYV PACTFGIGQK ARLVFGHDVN LLRYFTTCGL QEGYQPFCVN
     MNRNMTFWYN KDEAVFVNVD DAFHPNVEVS RIPAGGECPP ALKIIHKLFE SVEKVNYEFL
     RLSLPVTCHD TLIEEIEKEQ RWEEIRRRQR RAQAERKSIR HPGEMVFLRQ QQHMLRSGFS
     MSDVKGVPDG SGSRLRAASS EEALTRIGQP HKGQRSKATT PEPEGKAKRR GKSPFRFFRS
     KKDEKEEKEP APAQPAPAAP KAPTPATLAP PMLTVRAPSV QRLTPAGSQL LCPPVPDRPS
     GLGGGGIPRT GSSRRPSLAP APPPADDTGD RLDPSVLDLV DEYFYGLRVS RADPSHVYCG
     WVTTRTVHDG AQHAKVRSLE RQNCYMVCAG QLATEISHGE AGSRSANQGM YVGCHIDLAT
     GMLTFSADGH ITRHRFKMEP GTKLYPAAFF EATSKEVLQF ELGHTPTTLP LSAALLHNTS
     RHLTPQLPPR LKVQCVQPYV WARVPNVSLR PHALRLSEVR GWSMLCEDPV SMLALHIPEE
     DRCIDILELI EHERLLNFHA HTLSLYGALC FQGNHRAAHM ICSHVDEKQL MYAIQAEYLS
     GPLRTGFTDL LISLHLEFHA YARSLTQNEF IVPLGPDIRE LYQDPLKAHS FTTLECISIR
     PEMSFSETRE QVDSIADLST PYFPVDALKQ FVIEALADAV KKDSRPNRDP IGGSNENLFV
     PLLKLADKLL LVGLLDDEDL QWLLYLLDPE TFDPNYRNAG NGGALGLIDM QVAEGVKLQI
     CYILHHLCDL QMRHRVEAIV SFSDDYVGNL QTDQLRRYIE IKQSDLPSSV AAKKTREFRC
     SPKEQMRAIL GFKHLEEENW DQCPCGEGLR EVLSSMHADQ LSRLKVATAA EEEAPEKEAD
     GDRSLRQRLM HLVSLVRASE EESGGGEERV TLPEARPSLR GSTPLDVAYS SLMENSELAL
     ALREHYLEKI AAYMSRCGLQ SNLELIDRGY PDVGWDPVEG ERYLDFLRFC VWVNGAFVGD
     APVWAYLVAR SRRTTLTWER PS
//
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