ID B7PA40_IXOSC Unreviewed; 256 AA.
AC B7PA40;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=PI3K/PI4K catalytic domain-containing protein {ECO:0000259|PROSITE:PS50290};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW016750 {ECO:0000313|EMBL:EEC03462.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03462.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03462.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016750-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016750-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010230842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010753999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010872052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS669002; EEC03462.1; -; Genomic_DNA.
DR RefSeq; XP_002406185.1; XM_002406141.1.
DR AlphaFoldDB; B7PA40; -.
DR STRING; 6945.B7PA40; -.
DR PaxDb; 6945-B7PA40; -.
DR EnsemblMetazoa; ISCW016750-RA; ISCW016750-PA; ISCW016750.
DR KEGG; isc:IscW_ISCW016750; -.
DR VEuPathDB; VectorBase:ISCI016750; -.
DR VEuPathDB; VectorBase:ISCP_027837; -.
DR VEuPathDB; VectorBase:ISCW016750; -.
DR HOGENOM; CLU_1088070_0_0_1; -.
DR InParanoid; B7PA40; -.
DR OMA; WCESMRE; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 163..256
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT NON_TER 256
FT /evidence="ECO:0000313|EMBL:EEC03462.1"
SQ SEQUENCE 256 AA; 28967 MW; 2F8C642BDFCA350F CRC64;
MDKLPLVSEF IEALELLQFP DVAFKNWCES MREALNNQKS VDVRKLYADG VRQLFGGQGR
DLALSSGGGI VHRHFSDVVK KKVTVAFGIE GSKLVKMDAK KFGSECQVIL KSYKSLEPTA
LKDLSPWLSR FSALDRDNKI EIPGQYTGRS KPMPEYHVNI FGFEESVLVL KSMQRPCRIT
IRGDDEKEHR FLVKTGEDLR QDDRIERLFG AMNALFTADP SCRAKHLQLV TYGVVPLTTR
VGLIEWLDGT VVLKDF
//
