ID B7PDC8_IXOSC Unreviewed; 565 AA.
AC B7PDC8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Integrin alpha-ps, putative {ECO:0000313|EMBL:EEC04600.1, ECO:0000313|EnsemblMetazoa:ISCW003187-PA};
DE EC=3.1.4.50 {ECO:0000313|EMBL:EEC04600.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW003187 {ECO:0000313|EMBL:EEC04600.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC04600.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC04600.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW003187-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW003187-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; ABJB010115042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010763053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010894118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS689337; EEC04600.1; -; Genomic_DNA.
DR RefSeq; XP_002410730.1; XM_002410685.1.
DR AlphaFoldDB; B7PDC8; -.
DR SMR; B7PDC8; -.
DR STRING; 6945.B7PDC8; -.
DR PaxDb; 6945-B7PDC8; -.
DR EnsemblMetazoa; ISCW003187-RA; ISCW003187-PA; ISCW003187.
DR KEGG; isc:IscW_ISCW003187; -.
DR VEuPathDB; VectorBase:ISCI003187; -.
DR VEuPathDB; VectorBase:ISCP_024727; -.
DR VEuPathDB; VectorBase:ISCW003187; -.
DR HOGENOM; CLU_482841_0_0_1; -.
DR InParanoid; B7PDC8; -.
DR OMA; RITIDIW; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0004621; F:glycosylphosphatidylinositol phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 1: Evidence at protein level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000313|EMBL:EEC04600.1};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PDC8};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 487..509
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 1..56
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 57..114
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 118..180
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 165..319
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 322..415
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT REGION 521..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC04600.1"
SQ SEQUENCE 565 AA; 61896 MW; 4110826D9EB542E5 CRC64;
SFQMGSYFGA SVLAIDLNMD NFTDLLVGAP LYSLQGTNGD EGKVYVYLSN GAVSILQDLK
IMGSSVPGAR FGSTIVNIGD LNLDGYPDVA IGSPYEHGYG AVYIYNGGKD GLKTTPAQII
EGRSTEGSPH GFGISISKAM DIDGNNYPDI VVGAYQSDQA YLFRAMPVVQ ARAWIEIDTK
HVSSNKPNCV RNNVAFFCFP VTPCIQYDGK YVPEQIDFEF TIEMDTKKQE AHRGAFELLG
GRTGISIREV RPLQRGRAMC FPQKALVFSN VQDLLTPFEF RLTFNISDGD KTRRDGFCST
CPVLDASTIT TVTNRTVFQV ACGPDNVCWA DLILKASIVG HEDSSPLVVG KDNVVSLAIS
VKNRDDTEPA YLSRVEISLP ENVDFVNIGT CESKGNATVS CDVGNPLNPG SEMVKYFDSP
INKVAVSISV PLKIHGKKDP FLKLEGVKNK VAKIELHMTL NVTRIMEQVI VTSLVKEGPP
APYRLPWWVY LLIVLGGLFL LLLIIYVLYR CGFFRRKAKE DLERSKRESL AASSVAHSPT
TENPPSMPGD DPEVRTSLLA PEARE
//
